Yoko Tsuchiya

Learn More
Rheumatoid arthritis is one of the most critical diseases that impair the quality of life of patients, but its pathogenesis has not yet been fully understood. Osteopontin (OPN) is an extracellular matrix protein containing Arg-Gly-Asp (RGD) sequence, which interacts with alpha(v)beta3 integrins, promotes cell attachment, and cell migration and is expressed(More)
A 19-year-old Japanese woman with Hashimoto's thyroiditis appeared to be hypothyroid by clinical and laboratory criteria. However, the serum levels of total T3 and free T3 as measured by solid-phase radioimmunoassay were not compatible with the clinical features and other laboratory data, therefore the presence of serum T3 autoantibodies was suspected. Gel(More)
BACKGROUND Cardiac myxomas are generally considered benign, but malignant tumors have been reported. Vascular endothelial growth factor (VEGF), an angiogenic factor, plays a role in the growth, progression, and metastasis of solid tumors and it has been reported that VEGF expression is upregulated in cardiac myxomas that have a high microvessel density. The(More)
BACKGROUND Fucosylated haptoglobin (Fuc-Hpt) is a novel cancer biomarker in a variety of pathological conditions. We previously found that the level of Fuc-Hpt is increased in the sera of patients with pancreatic cancer, and established a lectin antibody ELISA using Aleuria aurantia lectin, which specifically binds to fucosylated residues on(More)
Since a number of recent reports (2,14) have shown that myotonic dystrophy (MyD) might be an inherited disorder of cell membranes, we studied erythrocytes of 10 patients with MyD to investigate the membrane abnormality. In the osmotical aspect, the relative hemolysis of erythrocytes in patients with MyD in a solution of 75 mM NaCl displayed almost half the(More)
BACKGROUND Rifabutin has been used clinically to combat tuberculosis as well as nontuberculosis Mycobacterium since 2008 in Japan. Uveitis associated with rifabutin is described in many reports, but none of these are of Japanese. We report three Japanese cases of nontuberculosis Mycobacterium with rifabutin-associated uveitis. CASE 1: A 91-year-old woman(More)
We studied the erythrocyte membrane proteins from patients with Duchenne muscular dystrophy (DMD) using SDS-polyacrylamide gel electrophoresis. Our observations were the following: (1) The electrophoretic densitogram of freshly prepared DMD-ghosts was similar to that of controls. After the extraction of spectrin from ghosts with 1 mmol/l EDTA, pH 8.0, the(More)
OBJECTIVES In Japan, mumps immunization is not mandatory, and the prevalence of mumps immunization among eligible children is only about 30%, raising concerns about increased risk of meningitis, encephalitis and deafness caused by mumps. In 2011, to understand why families are not voluntarily immunizing their children against mumps, we surveyed mothers who(More)
Japan is facing an unprecedented aging society. In 2013, 25.1% of the total population in Japan was 65 years old and over. One third of the population in Japan will be at least 65 years old in 2035; healthy aging is crucial for public health and society in Japan. Under the budget limitations of social security, policies and frequent policy changes have(More)
PURPOSE To investigate the morphologic characteristics of the medial rectus muscle in patients with consecutive exotropia. DESIGN Retrospective, nonrandomized, interventional study. PARTICIPANTS AND CONTROLS Eleven eyes of 10 patients with consecutive exotropia were studied. Thirteen eyes of 13 age-matched normal subjects were studied as controls. (More)
  • 1