Yoko Ikegami

Learn More
Transdifferentiation from retinal pigment epithelium (RPE) to neural retina (NR) was studied under a new culture system as an experimental model for newt retinal regeneration. Adult newt RPEs were organ cultured with surrounding connective tissues, such as the choroid and sclera, on a filter membrane. Around day 7 in vitro, lightly pigmented "neuron-like(More)
Complete retinal regeneration in adult animals occurs only in certain urodele amphibians, in which the retinal pigmented epithelial cells (RPE) undergo transdifferentiation to produce all cell types constituting the neural retina. A similar mechanism also appears to be involved in retinal regeneration in the embryonic stage of some other species, but the(More)
Oxaliplatin is a key drug for colorectal cancer, but it causes acute peripheral neuropathy (triggered by cold) and chronic neuropathy (sensory and motor neuropathy) in patients. Neurotropin, a non-protein extract from the inflamed rabbit skin inoculated with vaccinia virus, has been used to treat various chronic pains. In the present study, we investigated(More)
Asynchronous cross-modal information is integrated asymmetrically in audio-visual perception. To test whether this asymmetry generalizes across modalities, auditory (aspirated "pa" and unaspirated "ba" stops) and tactile (slight, inaudible, cutaneous air puffs) signals were presented synchronously and asynchronously. Results were similar to previous AV(More)
Serotonin (5-HT) caused immediate elevation of intracellular Ca2+ concentration ([Ca2+]i) in blood platelets, and it was completely inhibited by 1 mM EGTA. In Ca2+ replenished platelets, however, 2 mM EGTA did not affect the 5-HT induced elevation of [Ca2+]i when EGTA was applied just before or during the stimulation by 5-HT. At the same concentration 5-HT(More)
Cytoplasmic free Ca2+ concentration, [Ca2+]i, was estimated in single rabbit blood platelets by digital imaging microscopy with the use of the specific Ca(2+)-indicator dye Fura-2. Uneven distribution and low level of [Ca2+]i was found in the resting platelet even in the presence of extracellular 1 mM Ca2+. Thrombin at 1 unit/ml immediately caused a(More)
1. INTRODUCTION Asynchronously presented auditory and visual information is integrated asymmetrically in speech perception [1, 2, 3]. For example, Munhall & al. [4] found that audiovisual integration of speech occurred even when the audio signal lagged the video signal by 240ms; however, when the audio signal preceded the video signal, perceivers only(More)
  • 1