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CSF-1R inhibition alters macrophage polarization and blocks glioma progression

• Stephanie M. Pyonteck, Leila Akkari, +17 authors Johanna A Joyce
• Nature Medicine
• 2013

Glioblastoma multiforme (GBM) comprises several molecular subtypes, including proneural GBM. Most therapeutic approaches targeting glioma cells have failed. An alternative strategy is to target cells… (More)

Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivo detection of mammary tumors and multiple metastases in immune deficient mice

• Darlene E. Jenkins, Yvette S. Hornig, Yoko A Oei, Joan M Dusich, Tony F Purchio
• Breast Cancer Research
• 2004

Our goal was to generate xenograft mouse models of human breast cancer based on luciferase-expressing MDA-MB-231 tumor cells that would provide rapid mammary tumor growth; produce metastasis to… (More)

Bioluminescent imaging (BLI) to improve and refine traditional murine models of tumor growth and metastasis

• Darlene E. Jenkins, Yoko A Oei, +4 authors Pamela Reilly Contag
• Clinical & Experimental Metastasis
• 2003

Bioluminescent imaging (BLI) permits sensitive in vivo detection and quantification of cells specifically engineered to emit visible light. Three stable human tumor cell lines engineered to express… (More)

CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells

• Debbie C Strachan, Brian Ruffell, +4 authors D. Daniel
• Oncoimmunology
• 2013

Increased numbers of tumor-infiltrating macrophages correlate with poor disease outcome in patients affected by several types of cancer, including breast and prostate carcinomas. The colony… (More)

Novel robust hepatitis C virus mouse efficacy model.

• Qing Zhu, Yoko A Oei, +5 authors Amy J Weiner
• Antimicrobial agents and chemotherapy
• 2006

The lack of a robust small-animal model for hepatitis C virus (HCV) has hindered the discovery and development of novel drug treatments for HCV infections. We developed a reproducible and easily… (More)

Imaging of bioluminescent LNCaP-luc-M6 tumors: a new animal model for the study of metastatic human prostate cancer.

• Caroline D. Scatena, Mischa A Hepner, +5 authors Darlene E. Jenkins
• The Prostate
• 2004

BACKGROUND Animal experiments examining hormone-sensitive metastatic prostate cancer using the human LNCaP cell line have been limited to endpoint analyses. To permit longitudinal studies, we… (More)

CHIR-258 is efficacious in a newly developed fibroblast growth factor receptor 3-expressing orthotopic multiple myeloma model in mice.

• Xiaohua Xin, Tinya J. Abrams, +11 authors Carla C. Heise
• Clinical cancer research : an official journal of…
• 2006

PURPOSE The ectopically expressed and deregulated fibroblast growth factor receptor 3 (FGFR3) results from a t(4;14) chromosomal translocation that occurs in approximately 15% of multiple myeloma… (More)

CHIR-258: a potent inhibitor of FLT3 kinase in experimental tumor xenograft models of human acute myelogenous leukemia.

• Daniel E Lopes de Menezes, Jing Peng, +10 authors Carla Heise
• Clinical cancer research : an official journal of…
• 2005

PURPOSE Fms-like tyrosine kinase 3 (FLT3) encodes a receptor tyrosine kinase (RTK) for which activating mutations have been identified in a proportion of acute myelogenous leukemia (AML) patients and… (More)

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