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Valid food-frequency questionnaires (FFQ) need to be developed to assess isoflavone intake in investigations of its possible association with the lower incidence of breast and prostate cancer in Asian countries. We investigated the validity and reproducibility of isoflavone (daidzein and genistein) intakes from self-administered semiquantitative FFQ used in(More)
A self-administered food frequency questionnaire (FFQ) has been used commonly in epidemiologic studies of diet and chronic diseases. The analysis of dietary data in the target population is useful for designing a new questionnaire. The authors studied the major food sources of nutrient intakes in the Japanese population in order to develop a FFQ for a(More)
There has been considerable controversy about the utility of asking separate questions on portion sizes in addition to items on consumption frequencies in food frequency questionnaires. One argument against this type of inquiry is that, for most foods, within-person variation of portion size is greater than between-person variation, making it difficult to(More)
Capsaicin (CAP; 50 mg/kg body wt., p.o.) and/or ethanol (EtOH; 10% (v/v) in the drinking water) were given for a period of 30 days to male rats, and changes in hepatic drug-metabolizing enzymes were investigated. The EtOH alone tended to increase the microsomal parameters such as cytochrome P-450 content and enzyme activities of aniline hydroxylase,(More)
The effects of a vitamin E (VE) deficient diet given for 120 days on total cytochrome P450 (P450) contents and UDP-glucuronyl transferase (UDPGT) and sulfotransferase (ST) activities were investigated in rat liver of both sexes. The VE deficient regimen lowered the serum VE levels, increasing the hepatic malondialdehyde concentration regardless of animal(More)
The effect of chronic salt loading on aortic components of connective tissue was evaluated in normotensive Wistar rats maintained on a high sodium chloride (NaCl; 8%) regime for a period of 30, 90, 180 and 360 days. The blood pressure remained unchanged until 90 days and was significantly elevated thereafter. The high NaCl diet for 180 days influenced(More)
OBJECTIVES To determine the effects of environmental factors on abnormalities in red blood cell deformability (RBCD), which may play an important role in the development of cardiovascular diseases, a cross-sectional epidemiological study was conducted in healthy subjects. METHOD The subjects were 350 males (mean age 52.7 +/- 10.3 SD) and 364 females (52.6(More)
We present here the survey methods and basic results of dietary records which were used as reference values in the present validation study of a self-administered food frequency questionnaire (FFQ) for the 5-year follow-up survey of the JPHC study. A semi-weighed dietary record was kept for four seven consecutive days in each of the four seasons in 3 areas,(More)
Objectives: To determine the extent to which interpopulation (between-population) variance, relative to intrapopulation (within-population) variance, contribute to the total variability in nutrient intakes.Design: Cross-sectional study.Setting: Five Public Health Center districts in Japan.Subjects: Two hundred and seven men and 183 spouses.Interventions: A(More)
The effect of excess sodium chloride (NaCl) intake on hepatic drug-metabolizing and glutathione-related enzyme systems in rats was investigated for a period of 360 days. There was no change in any parameters studied until day 180 of the experiment. However, feeding of a 8% NaCl diet for 360 days produced a decrease in cytochrome P-450 content and an(More)