Yoichiro Takahashi

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BACKGROUND Attitudes of healthcare professionals regarding spontaneous reporting of adverse drug reactions (ADRs) in Japan are not well known, and Japan's unique system of surveillance, called early post-marketing phase vigilance (EPPV), may affect these reporting attitudes. Our objectives were to describe potential effects of EPPV and to test whether ADR(More)
BACKGROUND Bevacizumab (Avastin(®)) was approved in Japan in April 2007 for patients with advanced or metastatic colorectal cancer. To address the limited clinical experience in Japanese patients, a post-approval surveillance study was undertaken in bevacizumab-treated patients in Japan. METHODS Bevacizumab (5 or 10 mg/kg every 2 weeks) was administered(More)
BACKGROUND Although several reports have suggested that patient-generated data from Internet sources could be used to improve drug safety and pharmacovigilance, few studies have identified such data sources in Japan. We introduce a unique Japanese data source: tōbyōki, which translates literally as "an account of a struggle with disease." OBJECTIVE The(More)
BACKGROUND The transfemoral approach has been a common technique for carotid artery stenting (CAS). When aortic or peripheral arterial conditions limit the transfemoral approach, the transbrachial approach may be used as an alternative. The purpose of our study was to report initial experiences of CAS with a novel sheath guide specifically designed for(More)
The aim of our retrospective study was to investigate the efficacy and safety of Yokukansan(TJ-54)in treating delirium during hospitalization following acute stroke. We retrospectively analyzed the patients 1)who were admitted to our single stroke center from January 2010 to December 2011 due to acute stroke within four days from onset, 2)who presented with(More)
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