Yoichi Oshima

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RATIONALE The (pro)renin receptor [(P)RR], encoded in ATP6AP2, plays a key role in the activation of local renin-angiotensin system (RAS). A truncated form of (P)RR, termed M8.9, was also found to be associated with the vacuolar H(+)-ATPase (V-ATPase), implicating a non-RAS-related function of ATP6AP2. OBJECTIVE We investigated the role of (P)RR/ATP6AP2(More)
The prorenin receptor is an accessory subunit of the vacuolar H(+)-ATPase, suggesting that it has fundamental functions beyond activation of the local renin-angiotensin system. Podocytes express the prorenin receptor, but its function in these cells is unknown. Here, podocyte-specific, conditional, prorenin receptor-knockout mice died of kidney failure and(More)
Prorenin receptor (PRR) is a multi-functioning protein possessing at least four different roles: (1) working as a receptor for renin and prorenin producing angiotensin I from angiotensinogen thus enhancing the tissue renin-angiotensin system; (2) inducing intracellular signals when a ligand binds to PRR; (3) participating in the functions of vacuolar proton(More)
Objective The management of blood pressure (BP) in hypertensive patients is the key to preventing a progression of organ damage. The brachial BP (bBP) has been used as the representative method for measuring the BP. The central BP (cBP), which is, different from the bBP due to the propagation and the reflection of the pulse wave in the arterial system, has(More)
Anti-programmed cell death-1 (PD-1) antibody therapy induces various adverse effects, especially in the endocrine system. Several cases of acute-onset insulin-dependent diabetes after anti-PD-1 antibody therapy have been reported. Many of these cases have a susceptible human leukocyte antigen (HLA) genotype for type 1 diabetes, possibly suggesting that HLA(More)
A 41-year-old man was referred to our hospital for the evaluation of hypergammaglobulinemia (IgG 2898 mg/dL and IgA 587 mg/dL), inflammation (CRP 6.7 mg/dL and serum interleukin-6 (IL-6) 15.1 ng/L), and anemia (Hb 10.9 mg/dL). Castleman’s disease (CD) was diagnosed by axillary lymph node biopsy. Five months later, painful purpura (multiple palpable 5 mm(More)
For given quasi-continuous functions g, h with g ≤ h and diffusion process M determined by stochastic differential equations or symmetric Dirichlet forms, characterizations of the value functions eg(s, x) = sup σ J (s,x) (σ) and ¯ w(s, x) = infτ sup σ J (s,x) (σ, τ) are well studied so far. In this paper, by using the time dependent Dirichlet forms, we(More)
Considering the value of semiconductor IP (Intellectual Property), fundamental knowledge of legal protection for IP is essential requirement for both IP providers and IP users. Since IPs are recognized as one of the intangible assets, present intellectual property system, such as patent, copyright, trade secret, and mask work protection system should(More)
For an irreducible symmetric Markov process on a, not necessarily compact, state space associated with a symmetric Dirichlet form, we give Poincaré type inequalities. As an application of the inequalities, we consider a time inhomogeneous diffusion process obtained by a time dependent drift transformation from a diffusion process and give general conditions(More)