Yoichi Oghiso

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Chronological changes in the chromosome aberration rates of splenocytes from specific-pathogen-free (SPF) mice after continuous and long-term exposure to low-dose-rate gamma rays were studied. Incidences of dicentrics plus centric rings (Dic+Rc), detected by conventional Giemsa staining, and dicentric chromosomes, detected by fluorescence in situ(More)
OBJECTIVE High-dose radiation exposure induces acute myeloid leukemia (AML) in C3H mice, most of which have a frequent hemizygous deletion around the D2Mit15 marker on chromosome 2. This region includes PU.1, a critical candidate gene for initiation of leukemogenesis. To identify novel cooperative genes with PU.1, relevant to radiation-induced(More)
Paclitaxel (Taxol), a yew-derived antimitotic agent which binds to microtubules, can mimic certain effects of lipopolysaccharide (LPS) on macrophages from LPS responder mouse strains. The production of nitric oxide (NO) by the peritoneal macrophages of LPS responder C3H/HeN mice stimulated with taxol or LPS was partially, but not completely, suppressed by(More)
Both prostaglandin E2 (PGE2)-dependent (indomethacin-sensitive) and PGE2-independent (indomethacin-insensitive) suppressor cell activities that inhibited mitogenic T cell blastogenesis appeared in the bone marrow and spleen of mice on days 20 to 30 following transplantation of NFSA fibrosarcoma molecularly expressing mRNA for both macrophage (M) and(More)
Based on the results of previous microarray analyses of murine NIH3T3/PG13Luc cells irradiated with continuous low-dose-rate (LDR) gamma-ray or end-high-dose-rate-irradiations (end-HDR) at the end of the LDR-irradiation period, the inverse dose-rate-effects on gene expression levels were observed. To compare differences of the effects between(More)
Dose-response relationships for the induction of micronuclei were characterised in the rat alveolar epithelial cell line (SV40T2) exposed to either alpha particles(241Am: 3.2 MeV, 128 keV.micron-1, 0.093 Gy.min-1 at the cell-Mylar interface) or X rays (200 kVp, 1 Gy.min-1). The frequency of micronucleus formation was 1.6-3.0% for unirradiated subjects but(More)
Dose responses were compared among primary lung tumors and their histological types induced by a single inhalation exposure of female Wistar strain rats to submicron-size and polydispersed aerosols of plutonium dioxide (239PuO2). While the primary lung tumors were found only in 2.3% of the unexposed control animals, the frequency of all the primary lung(More)
Female C3H/He mice, aged 12-17 weeks, were injected intravenously with 89SrCl2 at doses of 0.74kBq g-1 body weight (low dose) or 74.0kBq g-1 (high dose). During the first week after injection, approximately 45% of the injected 89Sr was excreted in the urine and feces in both dose groups. The excretion of 89Sr decreased thereafter. The total excretion up to(More)
Female Wistar strain rats were exposed to a single inhalation of a submicron-size aerosol of high-fired 239PuO2 to investigate pulmonary carcinogenesis during lifespan periods. The absorbed lung doses of the exposed animals ranged from 0.6 to 12 Gy and were well correlated with the initial lung deposition (ILD) of 0.1 to 2.3 kBq. Survival and induction of(More)
Measuring global gene expression using cDNA or oligonucleotide microarrays is an effective approach to understanding the complex mechanisms of the effects of radiation. However, few studies have been carried out that investigate gene expression in vivo after prolonged exposure to low-dose-rate radiation. In this study, C57BL/6J mice were continuously(More)