Yohichiro Kojima

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Snoring was once regarded as an indication of good sleep. But recently it has been known to be one of the symptoms which indicate sleep disordered breathing such as sleep apnea syndrome. Moreover, heavy snoring caused by oral breathing sometimes leads benign snorers to be apneics. Thus, it is important to detect oral snoring for medical treatment in the(More)
Polyethylenimine (PEI) is one of the most versatile non-viral vectors used in gene therapy, especially for delivering plasmid DNA to human cells. However, a good understanding of PEI binding to DNA, the fundamental basis for the functioning of PEI as a vector, has been missing in the literature. In this study, PEI (branched, 600 Da) binding to DNA was(More)
The amide and ester carbonyl groups of four piperazin-2-one derivatives (N,N'-ethylene-bridged dipeptide ethyl esters) constructed from (R)- or (S)-phenylalanine and glycine were reduced with borane-tetrahydrofuran complex to produce the corresponding piperazine derivatives in 70-80% yields. These piperazin-2-one or piperazine derivatives were used as the(More)
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