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Effect of N-Phenylanthranilic Acid Scaffold Nonsteroidal Anti-inflammatory Drugs on the Mitochondrial Permeability Transition.
TLDR
The relationship between the dynamic structures and swelling induced by NPA scaffold NSAIDs was examined, and the solvation free energies (dGWs: an index of stereo-hydrophobicity) of the conformers obtained were determined using a molecular orbital analysis. Expand
Cytolytic Activity and Molecular Feature of Cardiotoxin and Cardiotoxin-like Basic Protein: The Electrostatic Potential Field Is an Important Factor for Cell Lytic Activity.
TLDR
The distribution of ESP fields may affect the cytolytic activity of the CT family and stereo-hydrophobicities and molecular torsions of CT and CLBP were similar. Expand
An Antitumor 2-Hydroxyarylidene-4-cyclopentene-1,3-Dione as a Protein Tyrosine Kinase Inhibitor: Interaction Between TX-1123 Derivatives and Src Kinase.
TLDR
Tyrphostin AG17 analogs, such as TX-1123, with Src kinase (Src-K), differed from each other, while their SRC-K inhibitory activities were affected by their fit in the S RCK molecule. Expand
Effects of the Nonsteroidal Anti-inflammatory Drug Celecoxib on Mitochondrial Function.
TLDR
Celecoxib dose-dependently induced mitochondria swelling and suppressed mitochondrial function, which was not suppressed by cyclosporine A (CsA), and oxygen consumption rate in mitochondria-suspended solution was facilitated by the addition of celecoxib, and its uncoupling activity was observed. Expand
Structure-associated Functional Control of TX-1877 Series by Glyco-conjugation
TLDR
The conformations and hydrophobicities of chemical compounds may be controlled by adding monosaccharide- and tetra-O-acetyl-conjugated sugars to TX-1877. Expand
Interactive Analysis of TX-1123 with Cyclo-oxygenase: Design of COX2 Selective TX Analogs.
TLDR
The COX-inhibitory activities of TX-1123 derivatives with the 2-hydroxyarylidene-4-cyclopentene-1,3-dione structure were examined, and the binding profiles of TX -1123 to COXs were analyzed using docking simulations. Expand
Construction of a Drug Release Evaluation System: Application of Mitochondrial Respiration to Monitor Drug Release
TLDR
A direct evaluation system for drug-release from model carrier was examined using the mitochondrial oxygen consumption rate as an index and the release profile reflected the molecular properties of the test drugs. Expand