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In most cases, development of Web-based systems has been ad hoc, lacking systematic approach and quality control and assurance procedures. Hence, there is now legitimate and growing concern about the manner in which Web-based systems are developed and their long-term quality and integrity. Web Engineering, an emerging new discipline, advocates a process and(More)
We have developed an in vitro model of adaptive cytoprotection induced by deoxycholate (DC) in human gastric cells and have shown that pretreatment with a low concentration of DC (mild irritant, 50 microM) significantly attenuates injury induced by a damaging concentration of DC (250 microM). This study was undertaken to assess the effect of the mild(More)
The workshop would assess the problems of Web-based application systems development, argue the need for Web Engineering approach for developing scalable, quality, large-scale Web-based systems. It would also identify key Web Engineering activities and propose approaches and methods for systematic development of Webbased applications. Further, it would(More)
Prostaglandins (PG) protect gastrointestinal cells against damage induced by ethanol (EtOH) and other noxious agents, a process termed cytoprotection. The present study investigated the relationships between microtubule (MT) stability, protein kinase C (PKC) activation, and calcium efflux as a possible mechanism of PG's protective action using a human(More)
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BACKGROUND The mechanism(s) whereby nonsteroidal anti-inflammatory drugs (NSAIDs) attenuate colorectal tumor growth remains poorly understood. This study determined if NSAIDs decreased epidermal growth factor (EGF)-induced proliferation in human colonic tumor (Caco-2) cells and whether this process involved the inhibition of prostaglandin (PG) synthesis. (More)
The majority of previous work investigating adaptive cytoprotection has involved in vivo studies, which have suggested that this protective response is in large part mediated by endogenous prostaglandins (PGs). The aim of this study was to investigate adaptive cytoprotection under in vitro conditions in human gastric cells and to better delineate the role(More)
The Web has very rapidly become central to many applications in diverse areas. As our reliance on Web-based applications continues to increase and the Web systems supporting these applications become more complex, there is growing concern about the manner in which the Web-based systems/applications are created and their quality, integrity and(More)