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We constructed an expression vector for a fusion protein [ANG II type 1a receptor-green fluorescent protein (AT(1a)R-GFP)] consisting of enhanced GFP attached to the COOH terminus of the rat AT(1a)R. Chinese hamster ovary (CHO) cells transfected with AT(1a)R-GFP demonstrated specific, high-affinity (125)I-labeled ANG II binding (IC(50) 21 nM). ANG II(More)
Background: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive multifactorial disease with limited treatment options. Aim: To evaluate the efficacy of glycosides based standardized fenugreek seed extract (SFSE-G) on behavioral, biochemical, molecular and ultrastructural changes in bleomycin (BLM) induced pulmonary fibrosis in the laboratory rats.(More)
Steroid responsiveness of peripheral blood T cells derived from steroid sensitive, steroid dependent, and steroid resistant asthmatics, and induction of steroid resistance by costimulatory signal Akio Mori, Akemi Abe, Satoshi Kouyama, Miyako Yamaguchi, Yo Iijima, Chihiro Mitsui, Chiyako Oshikata, Hidenori Tanimoto, Kiyoshi Sekiya, Takahiro Tsuburai, Masami(More)
Methods For in vitro evaluation of steroid sensitivity, ovalbumin (OVA) reactive Th clones were cultured with antigen presenting cells and OVA in the presence of various concentrations of dexamethasone (DEX). Proliferative responses of Th clones were measured by H-thymidine incorporation. For in vivo evaluation, unprimed BALB/c mice were transferred with Th(More)
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