Yngve Kvinnsland

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Intercellular variations in the level of antigen expression and in cellular and nuclear radii were taken into account in a model used to estimate cell survival for an in vitro experiment with antibodies containing alpha-particle emitters that target the cell surface. Using measured variations in these characteristics for cells of two human cancer cell(More)
BACKGROUND A systematic comparison of magnetic resonance imaging (MRI) options for glioma diagnosis is lacking. PURPOSE To investigate multiple MR-derived image features with respect to diagnostic accuracy in tumor grading and survival prediction in glioma patients. MATERIAL AND METHODS T1 pre- and post-contrast, T2 and dynamic susceptibility contrast(More)
Electron dose distributions below bolus edges of various thicknesses and angles were measured using a diode in a water phantom. The measurements were compared with treatment planning calculations using the gamma method. Below 5 mm boluses, the dose variations were acceptable for all angles, while for boluses thicker than 5mm, the lowest edge gave the(More)
This report presents a VR system for evaluation of treatment plans used in radiotherapy (RT), developed to improve the understanding of the spatial relationships between the patient anatomy and the calculated dose distribution. The VR system offers visualization through interactive volume rendering of RT dose distribution and computed tomography (CT) and(More)
The biological effect of a radiopharmaceutical depends heavily on the heterogeneity of the uptake in the various tissues. A comparative study of two radiopharmaceuticals should therefore include a comparison of the uptake patterns in different tissues. To eliminate the problems caused by variation in kinetics and tumour characteristics between individuals,(More)
INTRODUCTION An increasing number of multimodal images represent a valuable increase in available image information, but at the same time it complicates the extraction of diagnostic information across the images. Multispectral analysis (MSA) has the potential to simplify this problem substantially as unlimited number of images can be combined, and tissue(More)
BACKGROUND AND PURPOSE To account for internal organ motion and set-up uncertainties around organs at risk (OR) in radiotherapy (RT), the ICRU report no 62 introduced the planning organ at risk volume (PRV). In the present study, we have quantified PRV margins for the intestine, which is an important OR in pelvic RT. MATERIALS AND METHODS The present(More)
PURPOSES The alpha-emitting radionuclide 211At conjugated to the CD20 targeting chimeric monoclonal antibody rituximab was studied to: (a) Estimate radiation dose components to lymphoma and bone marrow (BM) cells exposed in vitro. (b) Calculate the mean absorbed radiation doses in various normal tissues of mice following intravenous injection. MATERIALS(More)
Intratumour heterogeneity in the uptake of blood-borne technetium-labelled human serum albumin ((99m)Tc-HSA) was studied in human melanoma xenografts in an attempt to identify transport barriers leading to inadequate and heterogeneous uptake of macromolecular therapeutic agents in tumours. The Bioscope imaging system, which can detect the distribution of(More)
BACKGROUND AND PURPOSE To derive planning organ at risk volume (PRV) margins for the rectum and to analyse the impact of such margins on rectum dose volume histograms (DVHs). PATIENTS AND METHODS Weekly repeat computer tomography (CT) scans of 19 bladder cancer patients acquired during a conformal radiotherapy course were registered with the corresponding(More)