Yizhong Bao

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Cadmium (Cd) is a well-established carcinogen, however, the underlying mechanism, especially the role of epigenetics in it, is still poorly understood. Our previous work has disclosed that when rats were exposed to 0.5mg CdCl2 (kgd) for 8 and 12 weeks, the growth of peripheral white blood cells (WBC) was obviously stimulated but no over-proliferation of(More)
PURPOSE To investigate the difference of cellular response between low-dose-rate (LDR) 125I seed irradiation and high-dose-rate (HDR) γ-irradiation in human lung cancer cells. METHODS AND MATERIALS A549 and NCI-H446 cells with or without wortmannin (WM) treatment were exposed to 125I seeds and γ-rays, respectively. Cell survival, micronuclei (MN)(More)
This work investigated the effects of chronic cadmium (Cd) exposure combined with γ-ray irradiation on the cytotoxicity and genotoxicity of peripheral blood cells and bone marrow cells in rats. Results showed that when the rats were exposed to low dose (LD) Cd of 0.1mg CdCl₂/(kgd) for 8 and 12 weeks, the Cd concentration in blood reached to 135-140 μg/L and(More)
Chelation therapy is a known effective method to increase the excretion of U(VI) from the body. Until now, no any uranium chelator has been approved for emergency medical use worldwide. The present study aimed to evaluate the efficacy of new ligand BPCBG containing two catechol groups and two aminocarboxylic acid groups in decorporation of U(VI) and(More)
Cadmium (Cd) can induce bone loss and osteoporosis. Histologic methods have shown that Cd can induce microarchitecture change of the trabecular bone. The aim of this study is to evaluate the imaging biomarkers of osteoporosis induced by Cd using micro-computed tomography (micro-CT). Twenty-four male Sprague-Dawley rats were randomly divided into four groups(More)
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