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NESCA, a newly discovered signaling adapter protein in the NGF-pathway, contains a RUN domain at its N-terminus. Here we report the crystal structure of the NESCA RUN domain determined at 2.0-Å resolution. The overall fold of the NESCA RUN domain comprises nine helices, resembling the RUN domain of RPIPx and the RUN1 domain of Rab6IP1. However, compared to(More)
In this paper, a novel technique is proposed to address the joint sampling timing acquisition for baseband and broadband power-line communication (BB-PLC) systems using Orthogonal-Frequency-Division-Multiplexing (OFDM), including the sampling phase offset (SPO) and the sampling clock offset (SCO). Under pairwise correlation and joint Gaussian assumption of(More)
The neurotrophin receptor p75(NTR) conveys multiple signals via its intracellular death domain. However, how the death domain is activated and interacts with downstream adaptors remains unclear. Here, we report two crystal structures of the p75(NTR) death domain in the form of a non-covalent asymmetric dimer and a Cys379-Cys379 disulfide bond linked(More)
Extreme learning machine (ELM) is one of the most important and efficient machine learning algorithms for pattern classification due to its fast learning speed. In this paper, we propose a new ensemble based ELM approach for cross-modality face matching. Different to traditional face recognition methods, the proposed approach integrates the voting-base(More)
Education informatization is paid more attention to the development of web technologies recent years. Finding an effective way to make the best of existed public education resource distributed in different areas is an emergent task. Cloud computing technology is popular and utilized in many fields, and many facts show that it's a good way to resolve the(More)
With the rapid development of the Internet Web 2.0 technology, the demands of large-scale distributed service and storage in cloud computing have brought great challenges to traditional relational database. NoSQL database which breaks the shackles of RDBMS is becoming the focus of attention. In this paper, the principles and implementation mechanisms of(More)
As a generalization of hesitant fuzzy set (HFS), hesitant fuzzy linguistic term set (HFLTS) deals with several values in a membership function in qualitative settings so that experts think of several possible linguistic values or richer expressions than a single term for an indicator, alternative, variable, etc. However, ranking alternatives expressed with(More)
Interval-valued intuitionistic fuzzy (IVIF) set (IV-IFS) is effective in dealing with fuzziness and uncertainty inherent in decision data derived from decision maker and the actions performed in multi-attribute decision making (MADM). Therefore, in this paper, we investigate the MADM problems with uncertain attribute weight information in the framework of(More)
PhiC31 integrase-mediated gene delivery has been extensively used in gene therapy and animal transgenesis. However, random integration events are observed in phiC31-mediated integration in different types of mammalian cells; as a result, the efficiencies of pseudo attP site integration and evaluation of site-specific integration are compromised. To improve(More)