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PURPOSE To assess the prevalence of refractive error and visual impairment in school-age children in a metropolitan area of southern China. METHODS Random selection of geographically defined clusters was used to identify children 5 to 15 years of age in Guangzhou. Children in 22 clusters were enumerated through a door-to-door survey and examined in 71(More)
Forkhead box O3 (FoxO3a) is a forkhead family transcription factor playing important roles in non-neuronal differentiation, metabolism, proliferation, and survival, but its role in neuronal differentiation remains unclear. In the present study, we investigated the role of FoxO3a in neuronal differentiation and its underlying mechanisms. Our results showed(More)
To take full advantage of the powerful computing capability of graphics processing units (GPU) to speed up local feature detection, we present a novel GPU-based scale invariant interest point detector, coined Harris-Hessian(H-H). H-H detects Harris points in low scale and refines their location and scale in higher scale-space with the determinant of Hessian(More)
PURPOSE To determine whether the overexpression of the proteasome catalytic beta5 subunit (PSMB5) can induce the expression of the catalytic subunits beta1 and beta2, enhance proteasome activity, and exert a cytoprotective effect in lens epithelial cells. METHODS Cells from the human lens epithelial cell line SRA01/04 (LECs) were stably transfected either(More)
To prevent pornography from spreading on the Internet effectively, we propose a novel method of adult image detection which combines bag-of-visual-words (BoVW) based on region of interest (ROI) and color moments (CM). The goal of BoVW is to automatically mine the local patterns of adult contents, called visual words. The usual BoVW method clusters visual(More)
Cystatin C (CysC) is a cysteine protease inhibitor and previous studies have demonstrated that increasing endogenous CysC expression has therapeutic implications on brain ischemia, Alzheimer’s disease, and other neurodegenerative disorders. Our previous reports have demonstrated that the autophagy pathway was activated in the brain after experimental(More)
BACKGROUND Studies have demonstrated that autophagy pathways are activated in the brain after experimental subarachnoid hemorrhage (SAH) and this may play a protective role in early brain injury. However, the contribution of autophagy in the pathogenesis of cerebral vasospasm (CVS) following SAH, and whether up-regulated autophagy may contribute to(More)
Translational control is crucial in the regulation of gene expression and deregulation of translation is associated with a wide range of cancers and human diseases. Ribosome profiling is a technique that provides genome wide information of mRNA in translation based on deep sequencing of ribosome protected mRNA fragments (RPF). RPFdb is a comprehensive(More)
The human lens is comprised largely of crystallin proteins assembled into a highly ordered, interactive macro-structure essential for lens transparency and refractive index. Any disruption of intra- or inter-protein interactions will alter this delicate structure, exposing hydrophobic surfaces, with consequent protein aggregation and cataract formation.(More)
—State-of-the-art near-duplicate image search systems mostly build on the bag-of-local features (BOF) representation. While favorable for simplicity and scalability, these systems have three shortcomings: 1) high time complexity of the local feature detection; 2) discriminability reduction of local descriptors due to BOF quantization; and 3) neglect of the(More)