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Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography. Part II: Amphetamine-Induced Dopamine Release in the Functional Subdivisions of the Striatum
- D. Martínez, M. Slifstein, M. Laruelle
- Biology, PsychologyJournal of cerebral blood flow and metabolism…
- 1 March 2003
Results show significant differences in the dopamine response to amphetamine between the functional subdivisions of the human striatum, which may be related to the asymmetrical feed-forward influences mediating the integration of limbic, cognitive, and sensorimotor striatal function via dopamine cell territories in the ventral midbrain.
Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography: I. Accuracy and Precision of D2 Receptor Parameter Measurements in Ventral Striatum
- O. Mawlawi, D. Martínez, M. Laruelle
- BiologyJournal of cerebral blood flow and metabolism…
- 1 September 2001
The demonstration of an appropriate accuracy and precision of D2 receptor measurement with [11C]raclopride in the VST is the first critical step toward the use of this ligand in the study of synaptic dopamine transmission at D2 receptors in theVST using endogenous competition techniques.
Prefrontal Dopamine D1 Receptors and Working Memory in Schizophrenia
Findings confirm that alteration of DLPFC D1 receptor transmission is involved in working memory deficits presented by patients with schizophrenia.
Increased synaptic dopamine function in associative regions of the striatum in schizophrenia.
- L. Kegeles, A. Abi-Dargham, M. Laruelle
- Psychology, MedicineArchives of general psychiatry
- 1 March 2010
These findings suggest that schizophrenia is associated with elevated dopamine function in associative regions of the striatum, and suggests that elevated subcortical dopamine function might adversely affect performance of the dorsolateral prefrontal cortex in schizophrenia.
Elevated Brain Cannabinoid CB1 Receptor Availability in Posttraumatic Stress Disorder: A Positron Emission Tomography Study
It is suggested that abnormal CB1 receptor-mediated anandamide signaling is implicated in the etiology of PTSD, and provide a promising neurobiological model to develop novel, evidence-based pharmacotherapies for this disorder.
Alcohol Dependence Is Associated with Blunted Dopamine Transmission in the Ventral Striatum
In vivo vulnerability to competition by endogenous dopamine: Comparison of the D2 receptor agonist radiotracer (–)‐N‐[11C]propyl‐norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer…
Results suggest that 71% of D2 receptors are configured in a state of high affinity for agonists in vivo, and [11C]NPA might provide a superior radiotracer to probe presynaptic DA function with PET in health and disease.
Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine.
- D. Martínez, R. Narendran, M. Laruelle
- Biology, PsychologyThe American journal of psychiatry
- 1 April 2007
Blunted dopamine transmission in the ventral striatum and anterior caudate was predictive of the choice for cocaine over money, and this impairment appears to play a critical role in relapse.
Imaging synaptic density in the living human brain
Use of the synaptic vesicle glycoprotein 2A (SV2A) radioligand [11C]UCB-J combined with positron emission tomography (PET) to quantify synaptic density in the living human brain is reported.
Lower serotonin transporter binding potential in the human brain during major depressive episodes.
Subjects with major depressive disorder in a major depressive episode have lower serotonin transporter binding potential in the amygdala and midbrain, compared to healthy subjects.