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Itch-specific neurons have been sought for decades. The existence of such neurons has been doubted recently as a result of the observation that itch-mediating neurons also respond to painful stimuli. We genetically labeled and manipulated MrgprA3+ neurons in the dorsal root ganglion (DRG) and found that they exclusively innervated the epidermis of the skin(More)
M. Ali Bangash,1 Joo Min Park,1,6 Tatiana Melnikova,2,6 Dehua Wang,4,6 Soo Kyeong Jeon,1 Deidre Lee,2 Sbaa Syeda,2 Juno Kim,1 Mehreen Kouser,3 Joshua Schwartz,1 Yiyuan Cui,4 Xia Zhao,4 Haley E. Speed,3 Sara E. Kee,3 Jian Cheng Tu,1 Jia-Hua Hu,1 Ronald S. Petralia,5 David J. Linden,1 Craig M. Powell,3 Alena Savonenko,2 Bo Xiao,1,4 and Paul F. Worley1,*(More)
mTor kinase is involved in cell growth, proliferation, and differentiation. The roles of mTor activators, Rheb1 and Rheb2, have not been established in vivo. Here, we report that Rheb1, but not Rheb2, is critical for embryonic survival and mTORC1 signaling. Embryonic deletion of Rheb1 in neural progenitor cells abolishes mTORC1 signaling in developing brain(More)
Production of reactive oxygen species (ROS) increases with neuronal activity that accompanies synaptic development and function. Transcription-related factors and metabolic enzymes that are expressed in all tissues have been described to counteract neuronal ROS to prevent oxidative damage. Here, we describe the antioxidant gene LanCL1 that is prominently(More)
Rheb1 is an immediate early gene that functions to activate mammalian target of rapamycin (mTor) selectively in complex 1 (mTORC1). We have demonstrated previously that Rheb1 is essential for myelination in the CNS using a Nestin-Cre driver line that deletes Rheb1 in all neural cell lineages, and recent studies using oligodendrocyte-specific CNP-Cre have(More)
Myelin Deficit of the central nervous system leads to several severe diseases in human, but lack definitive diagnostic test. In this work, we proposed and performed terahertz spectroscopy and sub-wavelength imaging combined with chemometric techniques to discriminate and evaluate the severity of myelin deficit in and rhesus monkey brains. We demonstrated(More)
Abstract: Chemical storage tank leakage in petrochemical wharf is a serious economic, environmental and safety problem. Risk assessment is an effective way to identify chemical storage tank hazards and provides a guide for accident prevention in petrochemical wharf enterprises. Based on the characteristics of chemical storage tank zone, this paper proposes(More)
While myelin deficit of the central nervous system leads to several severe diseases, the definitive diagnostic means are lacking. We proposed and performed terahertz time-domain spectroscopy (THz-TDS) combined with chemometric techniques to discriminate and evaluate the severity of myelin deficit in mouse and rhesus monkey brains. The THz refractive index(More)
Excessive food/energy intake is linked to obesity and metabolic disorders, such as diabetes. The hypothalamus in the brain plays a critical role in the control of food intake and peripheral metabolism. The signaling pathways in hypothalamic neurons that regulate food intake and peripheral metabolism need to be better understood for developing(More)
Apoptosis is one kind of programmed cell death and contributes to development of a variety of organs such as brain. PNAS4 has been reported to be a novel apoptosis-related gene. Overexpression and knocking down of PNAS4 would cause zebrafish and Xenopus lavis developmental abnormalities. But its function and apoptotic mechanism in mammals are still unknown.(More)