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Although apolipoprotein E (APOE) variants are associated with age-related diseases, the underlying mechanism is unknown and DNA methylation may be a potential one. With methylation data, measured by the Infinium Human Methylation 450 array, from 993 participants (age ranging from 18 to 87 years) in the Genetics of Lipid Lowering Drugs and Diet Network(More)
Genetic understanding of complex traits has developed immensely over the past decade but remains hampered by incomplete descriptions of contribution to phenotypic variance. Gene-environment (GxE) interactions are one of these contributors and in the guise of diet and physical activity are important modulators of cardiometabolic phenotypes and ensuing(More)
OBJECTIVE Autosomal dominant polycystic kidney disease (ADPKD) is a relentlessly progressing form of chronic kidney disease for which there is no cure. The aim of this study was to characterize Chinese patients with ADPKD and to identify the factors which predict cyst growth and renal functional deterioration. METHODS To analyze disease predicting factors(More)
BACKGROUND Idiopathic membranous nephropathy (IMN) is the most common pathological type for nephrotic syndrome in adults in western countries and China. The benefits and harms of immunosuppressive treatment in IMN remain controversial. OBJECTIVES To assess the efficacy and safety of different immunosuppressive agents in the treatment of nephrotic syndrome(More)
Cyclosporine A (CsA) is an immunosuppressant agent and is utilized as a second-line drug therapy for refrac-tory nephrotic syndrome (RNS). In general, the use of CsA is strictly controlled in patients with an estimated glomerular filtration rate (eGFR) <30-40 ml/min/1.73 m 2 , and little is known about the safety and efficacy of CsA treatment in patients(More)
BACKGROUND Neighboring genes PIK3CA and KCNMB3 are both important for insulin signaling and β-cell function, but their associations with glucose-related traits are unclear. OBJECTIVE The objective was to examine associations of PIK3CA-KCNMB3 variants with glucose-related traits and potential interaction with dietary fat. DESIGN We first investigated(More)
With the rapid grows of cloud-based internet application, a need for efficient resource allocation, load balance and cost management increases. In this paper, we propose a group-auction based mechanism for the cloud instance market to efficiently allocate resources. In the market system, resource providers offer resources in the form of virtual machine.(More)
According to most existing auction mechanism paying great attention to the study of benefit maximization, being oblivious to the auction mechanism for the breadth of the influence of resource allocation, and to some extent, it restricted the resources promotion during the participants. This paper introduces a design to achieve the objective of maximizing(More)
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