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Intracellular tumor antigens presented on the cell surface in the context of human leukocyte antigen (HLA) molecules have been targeted by T cell–based therapies, but there has been little progress in developing small-molecule drugs or antibodies directed to these antigens. Here we describe a bispecific T-cell engager (BiTE) antibody derived from a T-cell(More)
PURPOSE The majority of tumor-specific antigens are intracellular and/or secreted and therefore inaccessible by conventional chimeric antigen receptor (CAR) T-cell therapy. Given that all intracellular/secreted proteins are processed into peptides and presented by class I MHC on the surface of tumor cells, we used alpha-fetoprotein (AFP), a specific liver(More)
Urban ecological security is the basic principle of national ecological security. However, analyses of the spatial and temporal dynamics of ecological security remain limited, especially those that consider different scenarios of urban development. In this study, an integrated method is proposed that combines the Conversion of Land Use and its Effects(More)
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