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Presenilin (PS1/PS2) is a major component of gamma-secretase, the activity that mediates proteolysis of beta-amyloid precursor protein to generate beta-amyloid (Abeta). Here we demonstrate that PS1, through its loop region, binds to phospholipase D1 (PLD1), thereby recruiting it to the Golgi/trans-Golgi network. Overexpression of wild-type PLD1 reduces(More)
BACKGROUND Appendectomy, the surgical removal of the appendix, is performed primarily for acute appendicitis. Patients who undergo appendectomy for complicated appendicitis, defined as gangrenous or perforated appendicitis, are more likely to suffer from postoperative complications. The routine use of abdominal drainage to reduce postoperative complications(More)
Emerging evidence suggests that FoxM1 may have a crucial role in the development and progression of human gastric cancer. Therefore, we sought to determine the role of FoxM1 in gastric cancer epithelial-mesenchymal transition (EMT). The down-regulation of FoxM1 expression by the transfection of cells with FoxM1 siRNA decreased cell migration, invasion, and(More)
In the present study, functionally active, recombinant chitribrisin, which is a thrombin-like enzyme in the venom of the Chinese green pit viper (Trimeresurus albolabris), was expressed and purified using a prokaryotic system. The fusion protein of chitribrisin, together with TrxA and 6x His via an E.coli expression vector pET-32a(+), was successfully(More)
Cracked teeth are usually found and easily ignored in clinic. If not found in time, they can lead to pulpitis and teeth fractures, which even can make the cracked teeth pulled out. The current treatments for cracked teeth include occlusal adjustments or preventive fillings, and the root canal therapy or complete crown restoration, which is decided according(More)
UNLABELLED Herpes simplex virus 1 (HSV-1) and HSV-2 infect many humans and establish a latent infection in sensory ganglia. Although some infected people suffer periodic recurrences, others do not. Infected people mount both cell-mediated and humoral responses, including the production of virus-neutralizing antibodies (Abs) directed at viral entry(More)
Background In paragonimiasis, the lungs and pleural cavity are the major target organs, and the central nervous system can also be affected. The liver is an organ in which ectopic paragonimiasis rarely occurs. Because the symptoms and examinations in hepatic paragonimiasis (HP) are not typical, the disease is often misdiagnosed in the clinic. Methods From(More)
Cu<sub>2</sub>ZnSnS<sub>4</sub> (CZTS) and Cu<sub>2</sub>ZnSnSe<sub>4</sub> (CZTSe) thin films were fabricated by successive electrodeposition of layers of precursor elements followed by sulfurization and selenization of an electrodeposited Cu-Zn-Sn-Se precursor. It is known that the Sn layer tends to have an island-shaped morphology, leading to formation(More)
Bile leak is one of the most common complications after hepatobiliary surgery. The current treatments for biliary leak include a variety of biliary drainage, re-operation and so on. However, widespread use of these nonsurgical or surgical therapies is restricted because of their own defects, such as bringing pancreatitis, hemorrhage, foreign body reaction(More)
OBJECTIVE The extracranial microanatomic features and tissue protection for supraorbital keyhole approach are described in detail to achieve less invasiveness, which has scant reports and is important for craniofacial surgeons. METHODS Ten formalin-fixed human cadaveric heads were used in 20 sides, by means of an operating microscopic, with(More)