Yixiang Cheng

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A novel visible light promoted carbodifluoroalkylation of allylic alcohols is disclosed. A series of difluoro 1,5-dicarbonyl compounds were obtained through a tandem radical addition and 1,2-aryl migration process. Mechanistic analysis indicated that the 1,2-aryl rearrangement proceeded via a radical intermediate.
A visible-light-induced decarboxylative trifluoromethylation of α,β-unsaturated carboxylic acids, which uses the Togni reagent as the CF3 source is disclosed. The corresponding trifluoromethylated alkenes were obtained in moderate to high yields with excellent functional group tolerance at ambient temperature. Preliminary mechanistic analyses suggest a(More)
The regeneration of cartilage, an aneural and avascular tissue, is often compromised by its lack of innate abilities to mount a sufficient healing response. Kartogenin (KGN), a small molecular compound, can induce bone marrow-derived mesenchymal stem cells (BMSCs) into chondrocytes. The previous in vitro study showed that kartogenin also had a(More)
A straightforward and efficient protocol for the construction of structurally and biologically interesting chiral flavanoids incorporating three privileged structures, i.e., chromanone, dihydropyran, and indole, has been developed on the basis of chiral bifunctional tertiary amine thiourea-catalyzed asymmetric inverse-electron-demand Diels-Alder reaction of(More)
Two coumarin salen-based sensors CS1 and CS2 can exhibit a pronounced fluorescence enhancement response toward Mg(2+) as high as 36-fold (CS1) and 111-fold (CS2) in the presence of Na(+) as a synergic trigger. More importantly, the fluorescent color of CS1 was bright green instead of weak yellow after the addition of Mg(2+) and Na(+) together, which can be(More)
A new N-doped carbon dots (NCDs) could be prepared by using the microwave-assisted technique within 10 min without the need for any solvent or catalyst. The NCDs exhibited a highly sensitive electrochemical response toward dopamine (DA) in Phosphate Buffered Saline (PBS) (pH=6.5). The detection limit of DA was calculated by differential pulse voltammetry(More)
A chiral polymer incorporating an (R,R)-salen moiety was synthesized by the polymerization of (R,R)-1,2-diaminocyclohexane with 2,5-dibutoxy-1,4-di(salicyclaldehyde)-1,4-diethynyl-benzene by a nucleophilic addition-elimination reaction. The fluorescence responses of the (R,R)-salen-based polymer toward various metal ions were investigated by fluorescence(More)
A facile in situ formed primary amine-imine organocatalyst was developed in the asymmetric Michael addition of substituted 4-hydroxycoumarins to cyclic enones. A series of optically active polycyclic coumarin derivatives were obtained in high yields with excellent enantioselectivities up to 97% ee.
A novel D-A conjugated polymer backbone containing silole and 9-octyl-9H-carbazole units was synthesized via Sonogashira reaction. This silole-containing polymer (SCP) was further used to prepare SCP dots with a nanoprecipitation method, which showed an electrochemiluminescence (ECL) emission at relatively low potential in aqueous solution. The strong(More)
A ruthenium-catalyzed direct C7 amidation of indoline C-H bonds with sulfonyl azides was developed. This procedure allows the synthesis of a variety of 7-amino-substituted indolines, which are useful in pharmaceutical. The good functional tolerances, as well as the mild conditions, are prominent feature of this method.