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BACKGROUND The associations of sarcopenia with adverse health status have highlighted the importance of sarcopenia research and intervention. This study was designed to analyze the characteristics of aging-related differences in appendicular skeletal muscle mass (ASM), handgrip strength (HS), gait speed (GS) and their associated factors in older Chinese, in(More)
This study investigates the age-related differences in skeletal muscle mass (SM), muscle strength and physical performance in mainland Chinese. Based on available data, the reference values (criteria) for the definition of sarcopenia in elderly Chinese were explored. Body composition measurements were obtained using a bioelectrical impedance analyzer (BIA);(More)
BACKGROUND AIMS Mounting evidence shows that non-cell-based transplantation of exosomes derived from mesenchymal stromal cells (MSCs) has more potential protective and reparative effects than MSCs have. However, whether it is safe to transplant MSC exosomes into tissues is still not clear. In this study, we evaluated the safety of transplantation of(More)
Reverse transcription quantitative-polymerase chain reaction (RT-qPCR) is a routine method for gene expression analysis, and reliable results depend on proper normalization by stable reference genes. Caloric restriction (CR) is a robust lifestyle intervention to slow aging and delay onset of age-associated diseases via inducing global changes in gene(More)
Sirtuin 1 (Sirt1) has a range of molecular functions and has emerged as an important protein in aging and metabolic regulations. Studies have reported a correlation between disturbance of Sirt1 activity and the onset of aging‑ or obesity‑associated diseases, including diabetes, cardiovascular disease and neurodegenerative disorders. However, a systematic(More)
Phosphorothioation, with sulfur replacing a nonbridging oxygen of phosphate, has surfaced in bacterial DNA electrophoresis. To understand structural characteristics of the thio-substituted DNA, we have investigated the correlation between the relative energy of phosphate/phosphorothioate linkage and the backbone torsions. The relative energies (R.E.)(More)
Depression is common among elderly people, but people from various study settings were at different levels of risk for depression. However, most of the existing studies were conducted among community population, and little was known about depression among institutionalized population. In this study, using a national sample, we aimed to compare the(More)
In many metropolitan areas, the urban fringe is defined by highly sensitive habitats such as forests and wetlands. However, the explosive growth of urban areas has led to the formation of informal settlements in the urban fringe, subsequently threatening these sensitive habitats and exaggerating several social and environmental problems. We seek to improve(More)
BACKGROUND/AIMS Insulin resistance in type 2 diabetes results from a combination of hyperglycemia and elevated free fatty acid (FFA) concentrations. However, the individual effects of glucotoxicity and lipotoxicity on cell function have not been determined. METHODS To compare the effects of increased FFAs and glucose levels on the PARP-NAD-SIRT1 pathway,(More)
Co-prime DFT filter banks provide an effective tool of spectral analysis in case that the sampling rate is far lower than the Nyquist sampling rate. However, since the practical prototype filters are not ideal, spurious peaks will occur in multiple locations when the frequency offsets of the stimulus components are close to half of the frequency resolution(More)