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Doxorubicin (DOX) is one of the most widely used and successful antitumor drugs, but its cumulative and dose-dependent cardiac toxicity has been a major concern of oncologists in cancer therapeutic practice for decades. With the increasing population of cancer survivors, there is a growing need to develop preventive strategies and effective therapies(More)
BACKGROUND Hashimoto's thyroiditis (HT) is the most common cause of hypothyroidism and is characterized by gradual autoimmune mediated thyroid failure with occasional goiter development. HT is seven times more likely to occur in women than in men. Papillary thyroid cancer (PTC), the most prevalent form of cancer in the thyroid, is 2.5 times more likely to(More)
For a Gray code in the scheme of rank modulation for flash memories, the codewords are permutations and two consecutive codewords are obtained using a push-to-the-top operation. We consider snake-in-the-box codes under Kendall’s τ -metric, which is a Gray code capable of detecting one Kendall’s τ -error. We answer two open problems posed by Horovitz and(More)
The centralized coded caching scheme is a technique proposed by Maddah-Ali and Niesen as a solution to reduce the network burden in peak times in a wireless network system. Yan et al. reformulate the problem as designing a corresponding placement delivery array and propose two new schemes from this perspective. These schemes above significantly reduce the(More)
Toxoplasma gondii is an important human and veterinary pathogen. The induction of bradyzoite development in vitro has been linked to temperature, pH, mitochondrial inhibitors, sodium arsenite and many of the other stressors associated with heat shock protein induction. Heat shock or stress induced activation of a set of heat shock protein genes, is(More)
BACKGROUND Ketamine, a noncompetitive N-methyl-D-aspartate receptor antagonist, is widely used as an intravenous anesthetic agent and has also been shown to possess anti-inflammatory effects, but its effects on high-mobility group box-1 (HMGB1) have not been well defined. In the present study, we investigated the effects of ketamine on HMGB1 in(More)
The problem of private information retrieval gets renewed attentions in recent years due to its information-theoretic reformulation and applications in distributed storage systems. PIR capacity is the maximal number of bits privately retrieved per one bit of downloaded bit. The capacity has been fully solved for some degenerating cases. For a general case(More)
As a hardware-oriented stream cipher, Trivium is on the edge of low cost and compactness. In this paper we discuss how brittle Trivium is under fault attack. Our fault model is based on the following two assumptions: (1)We canmake fault injection on the state at a random time and (2) after each fault injection, the fault positions are from random one of(More)
We examined the effects of diallyl disulfide (DADS), an oil-soluble organosulfur compound found in garlic, on human HepG2 hepatoma cells to better understand its effect on apoptosis and apoptosis-related genes. Our study has demonstrated that DADS affects cell proliferation activity and viability and elicits typical apoptotic morphologic changes (chromatic(More)
Pathological cardiac hypertrophy caused by diverse etiologies eventually leads to cardiac dilation and functional decompensation. We have recently reported that genetic deletion of Rho-associated coiled-coil containing protein kinase 1 (ROCK1) inhibited several pathological events including cardiomyocyte apoptosis in compensated hypertrophic hearts. The(More)