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Transitioning an infrastructure the size of the Internet is no small feat. We are in the midst of such a transition, <i>i.e</i>., from IPv4 to IPv6. IPv6 was standardized 15 years ago, but until recently there were few incentives to adopt it. The allocation of the last large block of IPv4 addresses changed that, and migrating to an IPv6 Internet has become(More)
The range of BRCA1/BRCA2 gene mutations is diverse and the mechanism accounting for this heterogeneity is obscure. To gain insight into the endogenous mutational mechanisms involved, we evaluated the association of specific sequences (i.e. CpG/CpNpG motifs, homonucleotides, short repeats) and mutations within the genes. We classified 1337 published(More)
PURPOSE The objectives of this study were to develop a stage-of-change classification system and to determine the degree to which various adult subgroups have adopted the behavioral changes necessary to achieve a low-fat and/or high-fiber diet as recommended by the Dietary Guidelines for Americans. DESIGN The study used a mail survey randomly sent to 7110(More)
Detection of genomic DNA copy number variations (CNVs) can provide a complete and more comprehensive view of human disease. It is interesting to identify and represent relevant CNVs from a genome-wide data due to high data volume and the complexity of interactions. In this paper, we incorporate the DNA copy number variation data derived from SNP arrays into(More)
1alpha,25-Dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)) is known to inhibit the proliferation and invasiveness of prostate cancer cells. However, 1alpha,25(OH)(2)D(3) can cause hypercalcemia and is not suitable as a therapeutic agent. 19-Nor-vitamin D derivatives are known to be less calcemic when administered systemically. In order to develop more potent(More)
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