Yitian Xu

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Mutations in Gap Junction beta1 (GJB1), the gene encoding the gap junction protein connexin32 (Cx32), cause the X-linked form of Charcot-Marie-Tooth disease (CMT1X), an inherited demyelinating neuropathy. We investigated the possibility that the expression of mutant Cx32 in other cells besides myelinating Schwann cells contributes to the development of(More)
As patient survival drops precipitously from early-stage cancers to late-stage and metastatic cancers, microRNAs that promote relapse and metastasis can serve as prognostic and predictive markers as well as therapeutic targets for chemoprevention. Here we show that miR-1269a promotes colorectal cancer (CRC) metastasis and forms a positive feedback loop with(More)
Least squares twin support vector machine (LS-TSVM) aims at resolving a pair of smaller-sized quadratic programming problems (QPPs) instead of a single large one as in the conventional least squares support vector machine (LS-SVM), which makes the learning speed of LS-TSVM faster than that of LS-SVM. However, same penalties are given to the negative samples(More)