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SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development.
SUMO-specific protease 2 (SENP2) has a broad de-SUMOylation activity in vitro. However, the biological function of SENP2 is largely unknown. Here, we show that deletion of SENP2 gene in mouse causes… Expand
Cyclin a but not cyclin D1 is essential for c‐myc‐modulated cell‐cycle progression
- Yitao Qi, Yiding Tu, +6 authors Z. Zhou
- Biology, Medicine
- Journal of cellular physiology
- 1 January 2007
The proto‐oncogene c‐myc is a key player in cell‐cycle regulation and is deregulated in a broad range of human cancers and cell proliferation disorders. Here we reported that overexpression of c‐myc… Expand
Cyclin A is essential for the p53-modulated inhibition from benzo(a)pyrene toxicity in A549 cells.
Benzo(a)pyrene (B(a)P) is an environment carcinogen that can enhance cell proliferation by disturbing the signal transduction pathways in cell cycle regulation. The p53 tumor suppressor as a cell… Expand
The over-expression of p53 H179Y residue mutation causes the increase of cyclin A1 and Cdk4 expression in HELF cells
- D. Yang, Yitao Qi, +6 authors Z. Zhou
- Medicine, Biology
- Molecular and Cellular Biochemistry
- 26 May 2007
Down-regulation of p53 expression has been found in a broad range of human cancers and cell proliferation disorders, indicating that p53 plays a key role in cell cycle regulation and tumor… Expand
Cytotoxicity of melittin and apamin in human hepatic L02 and HepG2 cells in vitro
Abstract The aim of this study is to investigate whether melittin and apamin exhibit any effect on human hepatic cells (L02 cells) and hepatocellular carcinoma cells (HepG2) growth through apoptosis.… Expand
BH3 mimetic ABT-263 enhances the anticancer effects of apigenin in tumor cells with activating EGFR mutation
BackgroundMutated epidermal growth factor receptor (EGFR) is one of the most successful targets in cancer targeted therapy. While this treatment has benefited many patients with an activating EGFR… Expand