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Kyoto Encyclopedia of Genes and Genomes were used for functional enrichment analysis of differentially expressed genes (DEGs). A protein‐protein interaction network was constructed, and the hub genes
Colorectal cancer (CRC) is one of the most common cancers of the digestive tract. Although numerous studies have been conducted to elucidate the cause of CRC, the exact mechanism of CRC developmentExpand
MiR-506 Targets UHRF1 to Inhibit Colorectal Cancer Proliferation and Invasion via the KISS1/PI3K/NF-κB Signaling Axis
TLDR
This study found that UHRF1 protein is highly expressed in CRC tissues and negatively correlated with KISS1 protein expression, and may be a new potential target molecule for future CRC metastasis treatment. Expand
MiR-202 inhibits the proliferation and invasion of colorectal cancer by targeting UHRF1.
TLDR
It is found that overexpression of miR-202 significantly inhibited the proliferation and invasion of HCT116 cells and UHRF1 expression in both CRC cell lines indicated the possibility that mi R-202 is under-expressed in CRC tissues, and that miR -202 inhibits the proliferationand invasion of CRC via targeting U HRF1. Expand
Identification of key candidate genes for colorectal cancer by bioinformatics analysis
Colorectal cancer (CRC) is one of the most common cancers of the digestive tract. Although numerous studies have been conducted to elucidate the cause of CRC, the exact mechanism of CRC developmentExpand
Meta-analysis of natural orifice specimen extraction versus conventional laparoscopy for colorectal cancer
TLDR
Pooled comparisons revealed that NOSES was superior to LAP surgery in terms of postoperative morbidity, postoperative pain, hospital stay, the time to first flatus, cosmetic results, and wound infections; however, NOSes was associated with a longer operative time. Expand
Multiple‐cumulative probabilities used to cluster and visualize transcriptomes
TLDR
Pearson's correlation coefficient of multiple‐cumulative probabilities (PCC‐MCP) of genes is used to define the similarity of gene expression behaviors to answer the challenge of the high‐dimensional MCPs. Expand
Integrative Analysis and Identification of an Excellent lncRNA Signature to Predict Prognosis in Patients With Colon Cancer
  • ZhiHua Chen, Yilin Lin, +4 authors Shao-Qin Chen
  • Medicine
  • 4 February 2021
TLDR
An lncRNA signature has strong robustness and can stably predict the prognosis of COAD in different platforms and may be implicated in COAD pathogenesis and metastasis and applied clinically as a prognostic marker. Expand
MicroRNA-124 and microRNA-378 inhibit the proliferation and invasion of colorectal cancer by upregulating KiSS1
TLDR
In an early study of melanoma cell lines, Lee et al. found that the KiSS1 gene is closely related to the occurrence and metastasis of various malignant cancers, including melanoma. Expand