Yishu He

Leonard D. Shultz1
Robert Y. Wilpan1
Jacquelyn Ames1
Stephen Byers Sampson1
Kevin D. Mills1
1Leonard D. Shultz
1Robert Y. Wilpan
1Jacquelyn Ames
1Stephen Byers Sampson
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Signaling through RAS/MAP kinase pathway is central to biology. ERK has long been perceived as the only substrate for MEK. Here, we report that HSF1, the master regulator of the proteotoxic stress response, is a new MEK substrate. Beyond mediating cell-environment interactions, the MEK-HSF1 regulation impacts malignancy. In tumor cells, MEK blockade(More)
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