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Activation-induced cytidine deaminase (AID) is required for somatic hypermutation and immunoglobulin class switching in activated B cells. Because AID has no known target-site specificity, there have been efforts to identify non-immunoglobulin AID targets. We show here that AID acts promiscuously, generating widespread DNA double-strand breaks (DSBs),(More)
Signaling through RAS/MAP kinase pathway is central to biology. ERK has long been perceived as the only substrate for MEK. Here, we report that HSF1, the master regulator of the proteotoxic stress response, is a new MEK substrate. Beyond mediating cell-environment interactions, the MEK-HSF1 regulation impacts malignancy. In tumor cells, MEK blockade(More)
To cope with proteotoxic stress, cells attenuate protein synthesis. However, the precise mechanisms underlying this fundamental adaptation remain poorly defined. Here we report that mTORC1 acts as an immediate cellular sensor of proteotoxic stress. Surprisingly, the multifaceted stress-responsive kinase JNK constitutively associates with mTORC1 under normal(More)
Activation induced cytidine deaminase (AID) is required for somatic hypermutation and immunoglobulin class switching in activated B cells. Because AID possesses no known target site specificity, there have been efforts to identify non-immunoglobulin AID targets. We show that AID acts promiscuously, generating widespread DNA double strand breaks (DSB),(More)
A high-quality MPEG-2 software decoder should support a good scalability performance for a wide range of video format, especially for the high-resolution MPEG-2 video (e.g., HDTV). However, It is found that the existing parallel decoder suffers significant performance degradation when decoding high-level MPEG2 video with the full system configuration, due(More)
of Thesis Presented to the Graduate School of the University of Florida in Partial Fulfillment of the Requirements for the Degree of Master of Science EFFICIENT BUFFERING CONTROL FOR A SOFTWARE-ONLY, HIGH-LEVEL, HIGH-PROFILE, MPEG-2 DECODER By Yishu He December 2002 Chair: Jonathan C.L. Liu Major Department: Computer and Information Science and Engineering(More)
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