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  • Tianzheng Yu, James L. Robotham, Yisang Yoon
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2006 (First Published: 21 February 2006)
  • Increased production of mitochondrial reactive oxygen species (ROS) by hyperglycemia is recognized as a major cause of the clinical complications associated with diabetes and obesity [Brownlee, M.Continue Reading
  • K V Prasad, Z Ao, +4 authors Stuart F. Schlossman
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1997 (First Published: 10 June 1997)
  • Members of the tumor necrosis factor receptor (TNFR) superfamily are important for cell growth and survival. In addition to providing costimulatory signals for cell proliferation, ligation of bothContinue Reading
  • Mei Nu Cui, Xiangna Tang, Whitney V. Christian, Yisang Yoon, Kim Tieu
  • Medicine, Biology
  • The Journal of biological chemistry
  • 2010 (First Published: 9 April 2010)
  • Mutations in the mitochondrial encoded protein PTEN-induced putative kinase 1 (PINK1) cause autosomal recessive Parkinson disease (PD). In mammalian cells, mutant PINK1 has been reported to promoteContinue Reading
  • Anikó Váradi, Linda I Johnson-Cadwell, Vincenzo Cirulli, Yisang Yoon, Victoria J Allan, Guy A. Rutter
  • Biology, Medicine
  • Journal of cell science
  • 2004 (First Published: 1 September 2004)
  • While the subcellular organisation of mitochondria is likely to influence many aspects of cell physiology, its molecular control is poorly understood. Here, we have investigated the role of theContinue Reading
  • Tianzheng Yu, Bong Sook Jhun, Yisang Yoon
  • Biology, Medicine
  • Antioxidants & redox signaling
  • 2011 (First Published: 1 February 2011)
  • Increased production of reactive oxygen species (ROS) from mitochondria is the main cause of hyperglycemic complications. We previously showed that hyperglycemic conditions induce mitochondrialContinue Reading