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On the origin and continuing evolution of SARS-CoV-2
The results suggest that the development of new variations in functional sites in the receptor-binding domain of the spike seen in SARS-CoV-2 and viruses from pangolin SARSr-CoVs are likely caused by mutations and natural selection besides recombination. Expand
microRNAs in the Same Clusters Evolve to Coordinately Regulate Functionally Related Genes
It is suggested that positive Darwinian selection might be the driving force underlying the formation and evolution of miRNA clustering and the functional co-adaptation between new and old miRNAs in the miR-17–92 cluster. Expand
Drosophila tsRNAs preferentially suppress general translation machinery via antisense pairing and participate in cellular starvation response
  • S. Luo, F. He, +4 authors J. Lu
  • Biology, Medicine
  • Nucleic acids research
  • 14 March 2018
The study suggests the tsRNA-mediated regulation might be crucial for the energy homeostasis and the metabolic adaptation in the cellular systems. Expand
Viscometric study on the specific interaction between proton‐donating polymers and proton‐accepting polymers
The interpolymeric specific interaction between proton-donating polymers (PDPs) and proton-accepting polymers (PAPs) was studied by viscometry. The intrinsic viscosities and Schultz-BlaschkeExpand
The cellular economy of the Saccharomyces cerevisiae zinc proteome.
Results confirmed the ability of replete cells to store excess zinc and suggested that the majority of zinc-binding sites on proteins in deficient cells are either unmetalated or mismetalated, supported by analysis of two abundant zinc proteins. Expand
Evolution, and functional analysis of Natural Resistance-Associated Macrophage Proteins (NRAMPs) from Theobroma cacao and their role in cadmium accumulation
Functional analysis by expression in yeast provided evidence that NRAMP5 encoded a protein capable of Cd2+ transport, and suggested this gene as a target for genetic selection/modification. Expand
Function and Evolution of Upstream ORFs in Eukaryotes.
The current understanding of uORF-mediated translational regulation from the perspective of functional and evolutionary genomics is reviewed and remaining gaps that deserve further study are addressed. Expand
Biosynthetic energy cost for amino acids decreases in cancer evolution
  • Hong Zhang, Yirong Wang, +5 authors J. Lu
  • Biology, Medicine
  • Nature Communications
  • 8 October 2018
It is shown that cancer cells evolve towards gene expression profiles that use amino acids with lower biosynthetic energy costs, and the potential prognostic utility of quantifying the extent of this adaptation is demonstrated. Expand
The Schizosaccharomyces pombe PPR protein Ppr10 associates with a novel protein Mpa1 and acts as a mitochondrial translational activator
Ppr10 functions as a general mitochondrial translational activator, likely through interaction with mitochondrial mRNAs and mitochondrial translation initiation factor Mti2, and that Ppr10 requires Mpa1 association for stability and function. Expand
Recent advances in ribosome profiling for deciphering translational regulation.
The key differences between many new experimental methods developed to investigate the biology of mRNA translation from different aspects and the conventional ribosome profiling approach are summarized. Expand