Yiqun Huang

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The present study aimed to investigate the involvement of the Suv39H1 histone methyltransferase in the epigenetic changes in the euchromatic promoter in gastric carcinoma. We retrospectively analyzed the protein of Suv39H1 and tri-methylated histone H3 lysine 9 (H3K9) and histone H3 lysine 4 (H3K4) in 175 cases of gastric carcinoma by immunohistochemistry.(More)
BACKGROUND We have previously studied the histone acetylation in primary human leukemia cells. However, histone H3 methylation in these cells has not been characterized. METHODS This study examined the methylation status at histone H3 lysine 4 (H3K4) and histone H3 lysine 9 (H3K9) in primary acute leukemia cells obtained from patients and compared with(More)
OBJECTIVE Since histone hypoacetylation due to excess histone deacetylases (HDACs) has been associated with transcriptional repression in leukemia, we aimed to determine deficient histone acetylation in patients with acute leukemia and the effect of its correction by an isothiocyanate. METHODS The acetylation status of histones H3 and H4 in cells from(More)
BACKGROUND We have previously demonstrated that phenylhexyl isothiocyanate (PHI), a synthetic isothiocyanate, inhibits histone deacetylases and remodels chromatins to induce growth arrest in HL-60 myeloid leukemia cells in a concentration-dependent manner. METHODS To investigate the effect of PHI, a novel histone deacetylases inhibitor (HDACi), on(More)
One crucial aspect of distributed data mining is privacy preserving. Secure multiparty computation (SMC) is a useful approach to solve privacy preserving in distributed data mining. When data is vertically partitioned, scalar product is a feasible tool to securely discover frequent itemsets of association rule mining. We first show that several of the(More)
AIMS To investigate the involvement of JARID1B histone methyltransferase in the epigenetic change of euchromatic promoter in mantle cell lymphoma (MCL) and acute leukemia. METHODS We retrospectively analyzed the protein of JARID1B and tri-methylated histone H3 lysine 4 (H3K4), histone H3 lysine 9 (H3K9), and cyclin D1 and Ki67 in 30 cases of MCL by(More)
G9a is a mammalian histone methyltransferase that contributes to the epigenetic silencing of tumor suppressor genes. Evidence suggests that G9a is required to maintain the malignant phenotype, but little documentation show the role of G9a function in mediating tumor growth. We retrospectively analyzed the protein of G9a and monomethylated histone H3 lysine(More)
Privacy preserving distributed data mining has become a promising research area. This paper addresses the problem of association rule mining where the global database is vertically partitioned. When transactions are distributed in different sites, scalar product is a feasible tool to discover frequent itemsets. We present a new protocol to compute scalar(More)
As the relevant government departments have not yet developed a relatively complete system of drug production, resulting in various manufacturers of different production standards, thereby increasing the hospital staff on the management of drugs and the use of difficult, may lead to unnecessary drug safety accidents. Therefore, the development of safe(More)