Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target
- Yiping Wen, Jing Cai, Yaya Hou, Zaiju Huang, Zehua Wang
- Biology, MedicineOncoTarget
- 22 March 2017
Up-to-date information regarding EZH2 expression patterns, functions, and molecular mechanisms in cancer stem cells in various malignant tumors are reviewed and the therapeutic potential of targeting EZh2 in tumors is discussed.
Absence of TolC Impairs Biofilm Formation in Actinobacillus pleuropneumoniae by Reducing Initial Attachment
The importance of TolC in the initial biofilm formation stage in A. pleuropneumoniae is demonstrated, which could have important clinical implications in developing new treatments against biofilm-related infections by A. Pleurop pneumoniae.
Prevalence and seroepidemiology of Haemophilus parasuis in Sichuan province, China
- Zhenghao Wang, Qin Zhao, Yiping Wen
- Medicine, BiologyPeerJ
- 30 May 2017
The results confirmed that the combined approach was dependable and revealed the diversity and distribution of serovars in Sichuan province, which is vital for efforts aimed at developing vaccine candidates allowing for the prevention or control of H. parasuis outbreaks.
HOTAIR maintains the stemness of ovarian cancer stem cells via the miR-206/TBX3 axis.
- Yifan Zhang, Jianfeng Guo, Zehua Wang
- BiologyExperimental Cell Research
- 6 August 2020
Mutation of I176R in the E coding region weakens Japanese encephalitis virus neurovirulence, but not its growth rate in BHK-21 cells
- Yuyong Zhou, Rui Wu, S. Cao
- BiologyArchives of Virology
- 6 February 2018
Using reverse genetic technology, this study provides evidence that this single E-I176R mutation does not affect virus growth in BHK-21 cells but significantly decreases JEV neurovirulence in mice.
Effect of cheY deletion on growth and colonization in a Haemophilus parasuis serovar 13 clinical strain EP3.
- Lvqin He, X. Wen, Yiping Wen
- BiologyGene
- 10 February 2016
Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis
- K. Frankowski, Chen Wang, Sui Huang
- Biology, ChemistryScience Translational Medicine
- 16 May 2018
It is discovered that metarrestin inhibited tumor invasion and metastasis in multiple mouse models of cancer and prolonged the animals’ survival, suggesting its potential relevance for translation to patients.
Prevalence, antimicrobial resistance profiles and virulence-associated genes of thermophilic Campylobacter spp. isolated from ducks in a Chinese slaughterhouse
- Xinfeng Han, Xingai Guan, L. Zou
- BiologyFood Control
- 1 October 2019
A TolC-Like Protein of Actinobacillus pleuropneumoniae Is Involved in Antibiotic Resistance and Biofilm Formation
TolC1 is required for biofilm formation and is a part of the MDR machinery of both planktonic and biofilm cells, which could supplement therapeutic strategies for resistant bacteria and bio film-related infections of A. pleuropneumoniae.
The arcA gene contributes to the serum resistance and virulence of Haemophilus parasuis serovar 13 clinical strain EP3.
- Lingqiang Ding, X. Wen, Yiping Wen
- BiologyVeterinary Microbiology
- 30 November 2016
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