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5-HT2 receptors mediate functional modulation of GABAa receptors and inhibitory synaptic transmissions in human iPS-derived neurons
TLDR
Serotonin increased the frequency of miniature inhibitory postsynaptic currents (mIPSCs), which could be mimicked by α-methylserotonin, a 5-HT2 receptor agonist, and DOI reduced both frequency and amplitude of mIPSCs, which suggested that in iPS-derived human neurons serotonin postsynaptically reduced GABAa receptor function through 5- HT2A/C receptors. Expand
Corticothalamic synchronization leads to c-fos expression in the auditory thalamus
TLDR
It is concluded that c-fos expression is not simply associated with firing rate, but also with neuronal firing pattern and burst firings that are synchronized with the cortical oscillations are proposed to lead to c- fos expression in the principal nuclei of the MGB. Expand
Activation of 5-HT2A/C receptor reduces glycine receptor-mediated currents in cultured auditory cortical neurons
TLDR
The results suggested that activation of 5-HT2A/C receptors might suppress cortical tonic inhibition mediated by GlyRs, and the findings would provide important insight into serotonergic modulation of tonic inhibitory tone mediated by nonsynaptic GlyRs. Expand
Encoding and Retrieval of Artificial Visuoauditory Memory Traces in the Auditory Cortex Requires the Entorhinal Cortex
TLDR
It is suggested that the entorhinal cortex is necessary for the encoding and involved in the retrieval of artificial visuoauditory memory in the auditory cortex, at least during the early stages of memory consolidation. Expand
Reprogramming somatic cells to cells with neuronal characteristics by defined medium both in vitro and in vivo
TLDR
This 5C medium not only provides a means to derive cells with neuronal characteristics without viral transfection in vitro but might also be useful to produce neurons in vivo for neurodegenerative disease treatment. Expand
Direct auditory cortical input to the lateral periaqueductal gray controls sound-driven defensive behavior
TLDR
A previously unexplored neural pathway is demonstrated in mice that projects directly from the auditory cortex to the lateral periaqueductal gray and controls noise-evoked defensive behaviors and is involved in controlling the threat-related behavior. Expand
Sequential EMT-MET induces neuronal conversion through Sox2
TLDR
The critical roles of the sequential EMT-MET were implicated in direct cell fate conversion in addition to reprogramming, embryonic development and cancer progression. Expand
Visuoauditory Associative Memory Established with Cholecystokinin Under Anesthesia Is Retrieved in Behavioral Contexts
TLDR
It is demonstrated that in male rodents under anesthesia, a visual stimulus was associated with electrical stimulation of the auditory cortex or natural auditory stimulus in the presence of cholecystokinin (CCK), which guided the animals' behavior in a two-choice auditory task and suggested that CCK-enabled visuoauditory association during anesthesia can be translated to the subsequent behavior action. Expand
Activation of 5-HT2A/2C receptors reduces the excitability of cultured cortical neurons
TLDR
It is revealed that activation of 5-HT2A/2C receptors reduces neuronal excitability, which would deepen the understanding of serotonergic modulation of cortical activities. Expand
Antagonism between the transcription factors NANOG and OTX2 specifies rostral or caudal cell fate during neural patterning transition
TLDR
The findings have uncovered a mutual antagonism between NANOG and OTX2 underlying cell fate decisions during neural patterning, critical for the regulation of early neural development in humans. Expand
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