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BACKGROUND Glioblastomas (GBM) are comprised of a heterogeneous population of tumor cells, immune cells, and extracellular matrix. Interactions among these different cell types and pro-/anti-inflammatory cytokines may promote tumor development and progression. AIMS The objective of this study was to develop a cytokine-related gene signature to improve(More)
BACKGROUND To date, no prognostic microRNAs (miRNAs) for isocitrate dehydrogenase 1 (IDH1) wild-type glioblastoma multiformes (GBM) have been reported. The aim of the present study was to identify a miRNA signature of prognostic value for IDH1 wild-type GBM patients using miRNA expression dataset from the The Cancer Genome Atlas (TCGA). METHODS(More)
Avermectins (AVEs), which are widely used for the treatment of agricultural parasitic diseases, belong to a family of 6,6-spiroketal moiety-containing, macrolide natural products. AVE biosynthesis is known to employ a type I polyketide synthase (PKS) system to assemble the molecular skeleton for further functionalization. It remains unknown how and when(More)
BACKGROUND The relative contribution of isocitrate dehydrogenase mutations (mIDH) and O6-methylguanine-DNA methyltransferase promoter methylation (methMGMT) as biomarkers in glioblastoma remain poorly understood. METHODS We investigated the association between methMGMT and mIDH with progression free survival and overall survival in a prospectively(More)
Human leukocyte antigen-G (HLA-G) is a tumor microenvironment molecule that is involved in the escape of cancerous tumors from host immune recognition and destruction. This study investigated the potential relationship between HLA-G expression levels and the sharpness of low-grade glioma tumor borders in magnetic resonance images. Preoperative T2-weighted(More)
Phase-stepping technique is applied to the analysis of fringe pattern images of BGAs (Ball Grid Arrays) obtained by shadow moiré. Sensitivity of the fringe pattern analysis is demonstrated to be significantly increased. Thermally induced warpage of BGAs is successfully measured in real-time as the sample is driven through a simulated reflow process. The(More)
Sequential turbocharging system is designed to enlarge the torque of diesel engine in part loaded conditions and reduce the brake specific fuel consumption. Hardware-in-the- loop simulation is a technology to design and test electronic controllers. In order to accelerate the development process and reduce the development cost, hardware-in-the-loop(More)
The thermally induced warpage of electronic substrates is a significant concern in manufacturing processes. The ability to evaluate substrate behavior with respect to temperature is particularly important to manufacturing engineers. Previous measurement of thermally induced warpage on Printed Circuit Boards (PCBs) using general Shadow Moiré cannot provide(More)
Aldehyde dehydrogenases (ALDH) is a family of enzymes including 19 members. For now, ALDH activity had been wildly used as a marker of cancer stem cells (CSCs). But biological functions of relevant isoforms and their clinical applications are still controversial. Here, we investigate the clinical significance and potential function of ALDH1A3 in gliomas. By(More)
Overexpression of human leukocyte antigen-G (HLA-G), a non-classical major histocompatibility complex class-I molecule associated with immunosuppression, has been reported in various human malignancies. In the present study, we examined the role of HLA-G in gliomas. Clinical characteristics, mRNA expression microarrays and follow-up data pertaining to 293(More)