Learn More
Preventing noise-induced hearing loss (NIHL) by antioxidants is based on the hypothesis that generation of reactive oxygen species is one of the causes of NIHL. alpha-Tocopherol is a naturally occurring antioxidant with no noticeable side effects. In this study, we attempted to protect guinea pigs from developing NIHL by administering alpha-tocopherol.(More)
Cochlear hair cells are a terminally differentiated cell population that is crucial for hearing. Although recent work suggests that there are hair cell progenitors in postnatal mammalian cochleae, isolation and culture of pure hair cell progenitors from a well-defined cochlear area have not been reported. Here we present an experimental method that allows(More)
Three highly oxygenated guaianolides were isolated from the aerial parts of Ajania fruticulosa along with 17 known phytochemicals including a triterpene (alpha-amyrin), two plant sterols (beta-sitosterol, daucosterol), four flavonoids (axillarin, centaureidin, santin and 5,7,4'-trihydroxy-3,3'-dimethoxyflavone), and ten sesquiterpenes(More)
OBJECTIVE To observe the expression of cationic stearylamine (SA) liposome mediated basic fibroblast growth factor/green fluorescence protein (bFGF/GFP) gene in the cochlea of guinea pig, and evaluate the protection and rescue action of bFGF against the damage caused by gentamicin. METHODS Thirty-six guinea pigs were divided into 3 experimental groups.(More)
Measurements of elastic constants of strained 200 and 400 nm thin films, as well as unstrained samples, of the colossal magnetoresistance (CMR) material La0.67Ca0.33MnO3 are presented. Since the peak resistance temperature of a strained CMR film decreases as the film thickness decreases, it is of interest to see if features in the elastic constants,(More)
OBJECTIVE To investigate the molecular basis of the voltage-gated Ca2+ channel (VGCC) which controls the afferent synaptic neurotransmitters release in inner hair cell and their cellular expression. METHOD In this study we used different and complementary approaches to determine which types of 4 subunits of VGCC were expressed in the organ of Corti. (More)
We report changes in variable-energy positron annihilation spectroscopy measurements on undoped hydrogenated amorphous silicon films after light soaking. The change, seen predominantly in the high momentum band of the annihilation radiation, is not reversed by thermal annealing. We suggest, following recent models of the Staebler-Wronski effect, that light(More)
OBJECTIVE To detect the expression of Aquaporin-1,3 in the cochlea and endolymphatic sac of guinea pig. METHOD Two-step immunohistochemical method and immunofluorescence was used to examine the expression of Aquaporin-1,3. RESULT Aquaporin-1 was expressed on the basilar part of spiral ligament, basal membrane of Corti's organ and epithelialis of scala(More)
XANES (X-ray Absorption Near Edge Structure) of TiN and TiO2 layers on various substrates have been investigated by comparing the theoretical L3,2 edge of titanium and K edges of nitrogen and oxygen of various crystals, including TiN, TiO, and hcp Ti. The theoretical work is based on the relativistic spin-polarized density functional theory with generalized(More)