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Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors
Antimetastatic Therapies of the Polysulfide Diallyl Trisulfide against Triple-Negative Breast Cancer (TNBC) via Suppressing MMP2/9 by Blocking NF-κB and ERK/MAPK Signaling Pathways
diallyl trisulfide inhibits MMP2/9 activity and the metastasis of TNBC cells, and emerges as a potential anti-cancer agent.
Extraction, characterization of a Ginseng fruits polysaccharide and its immune modulating activities in rats with Lewis lung carcinoma.
Effect of cabazitaxel on macrophages improves CD47-targeted immunotherapy for triple-negative breast cancer
The results show that targeting macrophages is a promising and effective strategy for TNBC treatment and the combination of CD47 blockade and macrophage activation by cabazitaxel synergizes to vastly enhance the elimination of TNBC cells.
Downregulation of Integrins in Cancer Cells and Anti-Platelet Properties Are Involved in Holothurian Glycosaminoglycan-Mediated Disruption of the Interaction of Cancer Cells and Platelets in…
Results suggested that both the antiplatelet properties and mitigation of the levels of cellular adhesion molecules contributed to the anticancer effects of hGAG, and might thus be exploited for clinical adjuvant therapy to attenuate tumor hematogenous metastasis.
Auricularia polytricha polysaccharides induce cell cycle arrest and apoptosis in human lung cancer A549 cells.
Modeling small cell lung cancer (SCLC) biology through deterministic and stochastic mathematical models
This work reviewed mathematical models that have been developed for biological sciences and applied them in the context of small cell lung cancer growth, mutational heterogeneity, and mechanisms of metastasis to further understand the biology of SCLC and ultimately develop novel therapeutics.
Role of immunotherapy and co-mutations on KRAS-mutant non-small cell lung cancer survival
Patients with KRAS mutations have a unique co-mutation phenotype that requires further investigation and immunotherapy seems to be an effective choice of treatment for KRAS positive patients in any treatment-line setting and yields better outcomes than conventional chemotherapy.
Inhibiting crosstalk between MET signaling and mitochondrial dynamics and morphology: a novel therapeutic approach for lung cancer and mesothelioma
It is reported that inhibiting MET activity with the tyrosine kinase inhibitor MGCD516 attenuates viability, migration, and invasion of non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma (MPM) cell lines in vitro and significantly retards tumor growth in vivo.
Total C-21 steroidal glycosides, isolated from the root tuber of Cynanchum auriculatum Royle ex Wight, attenuate hydrogen peroxide-induced oxidative injury and inflammation in L02 cells
- Zhen-hui Wu, Yingyu Wang, Yunru Peng
- Biology, ChemistryInternational journal of molecular medicine
- 25 September 2018
It is demonstrated that TCSGs can protect L02 cells against H2O2-induced oxidative toxicity and inflammatory injury by increasing the expression of Nrf2 and HO-1, mediated by the NF-κB signaling pathway.