Yingrui Wang

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cGMP serves as the main second messenger of nitric oxide (NO). Antifibrotic effects of enhancing renal cGMP levels have recently been documented in experimental acute anti-Thy-1 glomerulonephritis. The present study compares the effects of the cGMP production-increasing soluble guanylate cyclase (sGC) stimulator BAY 41-2272 with those of the cGMP(More)
BACKGROUND Activation of soluble guanylate cyclase and generation of cyclic 3',5'-guanosine monophosphate (cGMP) is the main signal transducing event of the L-arginine-nitric oxide pathway. The present study analyzes the expression and activity of the nitric oxide-cGMP signaling cascade in and the effect of the specific soluble guanylate cyclase stimulator(More)
BACKGROUND A critical role of soluble guanylate cyclase and nitric oxide-dependent cyclic 3',5'-guanosine monophosphate (cGMP) production for glomerular matrix expansion has recently been documented in a rat model of acute anti-thy1 glomerulonephritis. The present study analyzes the renal activity of the nitric oxide-cGMP signaling cascade in and the effect(More)
Tubulointerstitial inflammation and fibrosis are hallmarks of chronic progressive renal diseases. To characterize the functional interaction between cell infiltration and matrix expansion, this study compared the immunosuppressant mycophenolate mofetil (MMF), intended as primarily anti-inflammatory intervention, the angiotensin-converting enzyme inhibitor(More)
BACKGROUND Progression is a hallmark of chronic renal disease and histologically characterized by fibrosis and inflammation of the tubulointerstitial compartment. To define the role of lymphocytes in this process, the novel lymphocyte-specific inhibitor FTY720 was administered to rats with anti-thy 1-induced chronic progressive glomerulosclerosis. In this(More)
Since high performance computing sustained petaflops in 2008, numerical simulation entered a new era to use 10K to 100K processor cores in one single run of parallel computing. In pursuit of petascale computing, the challenges of scalability must be addressed. Petapar is a highly scalable simulation framework which implements two popular meshfree/particle(More)
To alleviate environmental pollution and improve the efficient use of energy, energy systems integration (ESI)—covering electric power systems, heat systems and natural gas systems—has become an important trend in energy utilization. The traditional power flow calculation method, with the object as the power system, will prove difficult in meeting the(More)
Although there exist much work on GPU acceleration on the SPH method, the focus so far has been on the Euler equations in fluid mechanics. This paper presents GPU acceleration on the SPH method for the Navier-Stokes equations for both solid and fluid mechanics. We investigate and compare three CPU-GPU coupling models in terms of one large-scale parallel(More)
To alleviate environmental pollution and improve the energy usage efficiency of terminals, energy systems integration (ESI) has become an important paradigm in the energy structure evolution. Power, gas and heat systems are becoming tightly interlinked with each other in ESI. The dispatching strategy of local-area ESI has significant impact on its(More)
1 Introduction 1 1.1 Pathogenesis and therapy of chronic progressive renal disease 2 1.1.1 Histological and molecular characteristics 2 1.1.2 The central role of TGF-beta in renal fibrosis 2 1.1.3 The sequence of phases leading to progressive renal fibrosis 3 1.1.4 Therapeutic approaches to chronic progressive renal disease 4 1.2 The L-arginine-NO pathway(More)