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Tubulointerstitial inflammation and fibrosis are hallmarks of chronic progressive renal diseases. To characterize the functional interaction between cell infiltration and matrix expansion, this study compared the immunosuppressant mycophenolate mofetil (MMF), intended as primarily anti-inflammatory intervention, the angiotensin-converting enzyme inhibitor(More)
cGMP serves as the main second messenger of nitric oxide (NO). Antifibrotic effects of enhancing renal cGMP levels have recently been documented in experimental acute anti-Thy-1 glomerulonephritis. The present study compares the effects of the cGMP production-increasing soluble guanylate cyclase (sGC) stimulator BAY 41-2272 with those of the cGMP(More)
BACKGROUND Activation of soluble guanylate cyclase and generation of cyclic 3',5'-guanosine monophosphate (cGMP) is the main signal transducing event of the L-arginine-nitric oxide pathway. The present study analyzes the expression and activity of the nitric oxide-cGMP signaling cascade in and the effect of the specific soluble guanylate cyclase stimulator(More)
BACKGROUND Progression is a hallmark of chronic renal disease and histologically characterized by fibrosis and inflammation of the tubulointerstitial compartment. To define the role of lymphocytes in this process, the novel lymphocyte-specific inhibitor FTY720 was administered to rats with anti-thy 1-induced chronic progressive glomerulosclerosis. In this(More)
BACKGROUND A critical role of soluble guanylate cyclase and nitric oxide-dependent cyclic 3',5'-guanosine monophosphate (cGMP) production for glomerular matrix expansion has recently been documented in a rat model of acute anti-thy1 glomerulonephritis. The present study analyzes the renal activity of the nitric oxide-cGMP signaling cascade in and the effect(More)
Since high performance computing sustained petaflops in 2008, numerical simulation entered a new era to use 10K to 100K processor cores in one single run of parallel computing. In pursuit of petascale computing, the challenges of scalability must be addressed. Petapar is a highly scalable simulation framework which implements two popular meshfree/particle(More)
Although there exist much work on GPU acceleration on the SPH method, the focus so far has been on the Euler equations in fluid mechanics. This paper presents GPU acceleration on the SPH method for the Navier-Stokes equations for both solid and fluid mechanics. We investigate and compare three CPU-GPU coupling models in terms of one large-scale parallel(More)
1 Introduction 1 1.1 Pathogenesis and therapy of chronic progressive renal disease 2 1.1.1 Histological and molecular characteristics 2 1.1.2 The central role of TGF-beta in renal fibrosis 2 1.1.3 The sequence of phases leading to progressive renal fibrosis 3 1.1.4 Therapeutic approaches to chronic progressive renal disease 4 1.2 The L-arginine-NO pathway(More)
Krüppel-like factor 4 (KLF4) is a kind of zinc finger transcription factor, which is involved in terminal differentiation of epithelial cells and reprogramming of somatic cells to induced pluripotent stem (iPS) cells in mammals. In the present study, we identified a full-length cDNA of Klf4 in Zhikong scallop Chamys farreri (Cf-Klf4) and found that Cf-Klf4(More)
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