Yingrong Coral Sung

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Owing to its tumor tropism and prolonged transgene expression, mesenchymal stem cell (MSC) has been considered as an ideal delivery vehicle for cancer gene therapies or therapeutic vaccines. In this study, we demonstrated that intratumoral (i.t.) injection of MSCs expressing modified interleukin-12 (MSCs/IL-12M) exhibited stronger tumor-specific T-cell(More)
IL-12p70 plays a pivotal role in regulating the Th1/Th2 balance in the initial stage of immune responses. In contrast, IL-12p40, which is produced excess over IL-12p70, has been known to down-regulate IL-12p70-mediated responses by acting as an antagonist. To investigate in vivo function of IL-12p40, RH7777 rat hepatoma cells were engineered to inducibly(More)
Long Term Evolution (LTE) and Worldwide Interoperability for Microwave Access (WiMAX) are two major technologies toward next-generation mobile broadband standards, which are both expected to provide higher throughput and lower transmission latency for mobile users. This paper measures and compares the latency and the throughput of Time Division-Long Term(More)
We examined the possibility that Sindbis virus, an alpha virus with a single-stranded RNA genome, would be applied for neuronal gene transfer. The recombinant defective Sindbis viruses were constructed by replacing the structural genes of Sindbis virus with genes encoding beta-galactosidase (rdSind-lacZ) or enhanced green fluorescent protein (rdSind-EGFP).(More)
CpG oligodeoxynucleotides (ODNs) are promising immunomodulatory agents for treating human diseases and vaccine development. Phosphodiester CpG ODNs were demonstrated to have poor immunostimulatory potentials for cytokine production. However, the conjugation of consecutive deoxyriboguanosine residues, called a dG run, at the 3' terminus of phosphodiester CpG(More)
The Bel1 protein of human foamy virus is a 300-amino-acid nuclear regulatory protein which transactivates the gene expression directed by the homologous long terminal repeat and the human immunodeficiency virus type 1 long terminal repeat. While previous reports suggested that the single basic domain of Bel1 from residues 211 to 222 and/or 209 to 226 is(More)
Evidence from clinical and experimental studies of human and chimpanzees suggests that hepatitis C virus (HCV) envelope glycoprotein E2 is a key antigen for developing a vaccine against HCV infection. To identify B-cell epitopes in HCV E2, six murine monoclonal antibodies (MAbs), CET-1 to -6, specific for HCV E2 protein were generated by using recombinant(More)
Recently, smartphones have been used as remote controllers for home appliances through con-nectivity of mobile telecom network or Wi-Fi. To control several home appliances in a room, a mechanism is required for a smartphone to correctly select the target appliance. Through the built-in electronic compass function in the smartphone, we propose a scheme(More)
Long Term Evolution (LTE) evolved from Universal Mobile Telecommunications System (UMTS), which utilizes IP Multimedia Core Network Subsystem (IMS) to provide voice service. In most existing commercial operations, the LTE networks provide zonal coverage as compared with UMTS networks which provide full service coverage. A User Equipment (UE) can initiate or(More)
Memory leaks generated by a running program may exhaust memory resources and degrade system performance. It is hard to reproduce these kinds of leaks, let alone to identify and fix them early in the development phase. Thus online memory leak detection is required. In this paper we propose a two-phase approach to the online memory leak detection problem for(More)