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The effects of atorvastatin on SDF-1α expression under acute myocardial infarction (AMI) are still unclear. Therefore, our present study is to investigate the roles and mechanisms of atorvastatin treatment on SDF-1α expression in rats with AMI. Male Sprague–Dawley rats were underwent permanent coronary artery ligation and randomly assigned into four groups(More)
OBJECTIVE To evaluate the relationship between pulse pressure index (PPI) and carotid intima-media thickness (CIMT). METHOD Observational trial was design and 342 patients newly diagnosed as hypertension without anti-hypertensive therapy were enrolled. According to the cut-off value of CIMT, 342 participants were divided into normal (< 0.9mm) and(More)
OBJECTIVES The aim of this study is to evaluate the relationship of miR-30 with office and ambulatory blood pressure parameters and carotid intima-media thickness (CIMT) in patients with hypertension and healthy controls. METHODS We assessed the expression level of miR-30 in 40 patients with essential hypertension and 40 healthy individuals. All patients(More)
OBJECTIVE Current study sought to evaluate the effects of obstructive sleep apnea (OSA) plus hypertension (HTN) on prevalent cardiovascular diseases (CVD). DESIGN AND METHOD This was a cross-sectional study and a total of 1889 subjects were enrolled. The apnea-hypopnea index (AHI) was measured by polysomnography and OSA degree was classified as mild (AHI(More)
OBJECTIVE To observe the long-term relationship between body mass index (BMI) and cardiovascular events in male elderly hypertensive patients. METHODS A total of 839 male elderly (>65 years old) hypertensive patients were included in this prospective study. Baseline data were obtained on January 2004 and participants were followed up yearly till January(More)
OBJECTIVES The role of microRNAs (miRs,miRNAs) in the pathogenesis of cardiovascular diseases such as hypertension, as well as their diagnostic potential, has recently attracted much attention. However, target-organ damage (TOD) of hypertension remains a substantial challenge due to the lack of specific biomarkers. The present study was undertaken to(More)
OBJECTIVE We retrospectively analyzed the causes, diagnosis, clinical characteristics, treatment and prognosis of 17 patients with rhabdomyolysis. METHODS Rhabdomyolysis cases diagnosed from January 2005 to March 2014 in our department were included. RESULTS A total of 17 rhabdomyolysis patients (male 13, mean age (60.4 ± 15.7) years) were analyzed.Four(More)
The present multicentre, prospective, open-label, single treatment arm study (Val-Perfect) examined the efficacy and tolerability of once-daily valsartan monotherapy (80 mg for two weeks, followed by 160 mg for eight weeks) in 195 Chinese patients with mild to moderate hypertension, using office, home, and ambulatory blood pressure (BP) monitoring.(More)
OBJECTIVE To characterize the clinical features of patients with cardiac amyloidosis (CA). METHODS Totally 42 patients with CA admitted to Guangdong General Hospital since 2008 were included and retrospectively analyzed in the present study. CA was confirmed by abdomen and endocardium biopsy examination. Clinical manifestations, electrocardiogram and(More)
Resistant hypertension is an intractable problem to patients and physicians. In recent decades, a substantial amount of basic and epidemiological studies provide us a vast number of valuable evidence and information about this once elusive disease. Better understanding about this entity could help physicians improve diagnostic and therapeutic accuracy. In(More)