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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
The yak genome and adaptation to life at high altitude
TLDR
Positively selected and rapidly evolving genes in the yak lineage are found to be significantly enriched in functional categories and pathways related to hypoxia and nutrition metabolism, which may have important implications for understanding adaptation to high altitude in other animal species and for Hypoxia-related diseases in humans. Expand
Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde.
TLDR
A myocardial protective effect of ALDH2 against I/R injury possibly through detoxification of toxic aldehyde and a differential regulation of autophagy through AMPK- and Akt-mTOR signalling during ischaemia and reperfusion, respectively is suggested. Expand
PTPIP51, a novel 14-3-3 binding protein, regulates cell morphology and motility via Raf-ERK pathway.
TLDR
It is demonstrated here, that PTPIP51 could regulate ERK activity on Raf level, since MEK inhibitor and dominant-negative Raf-1 but not Ras could inhibit the ERK activation induced by P TPIP51. Expand
Down-regulation of CMTM8 Induces Epithelial-to-Mesenchymal Transition-like Changes via c-MET/Extracellular Signal-regulated Kinase (ERK) Signaling*
TLDR
CMTM8 down-regulation induces epithelial-to-mesenchymal transition (EMT)-like phenotypes via c-MET/ERK signaling and promotes an EMT-like change in MCF-10A cells, indicating a broader role for CMTM 8 in regulating cellular transformation. Expand
Chronic akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy
TLDR
The data suggest that Akt may accentuate aging-induced cardiac geometric and contractile defects through a loss of autophagic regulation. Expand
PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway.
TLDR
PDCD10 modulation of ERK signaling was mediated by MST4, and PDCD10 could be a regulatory adaptor necessary for M ST4 function, suggesting a link between cerebral cavernous malformation pathogenesis and the ERK-MAPK cascade via PDCD 10/MST4. Expand
Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)
TLDR
Taken together, CKLF1 is a novel functional ligand for CCR4, which could be desensitized by TARC/CCL17 and markedly inhibited by PTX. Expand
Single-agent arsenic trioxide in the treatment of children with newly diagnosed acute promyelocytic leukemia.
TLDR
The results indicate the high efficacy and safety of single-agent ATO regimens in the treatment of children with de novo APL, which are comparable with results achieved by the use of ATRA plus chemotherapy, which is the standard therapy for APL. Expand
Cardiomyocyte-specific deletion of endothelin receptor A rescues aging-associated cardiac hypertrophy and contractile dysfunction: role of autophagy
TLDR
The data suggest that cardiac ETA receptor ablation protects against aging-associated myocardial remodeling and contractile dysfunction possibly through autophagy regulation. Expand
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