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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
Autophagy Benefits the Replication of Newcastle Disease Virus in Chicken Cells and Tissues
TLDR
It is demonstrated that NDV infection induced steady-state autophagy in chicken-derived DF-1 cells and in primary chicken embryo fibroblast (CEF) cells, evident through increased double- or single-membrane vesicles, the accumulation of green fluorescent protein (GFP)-LC3 dots, and the conversion ofLC3-I to LC3-II. Expand
Chicken STING Mediates Activation of the IFN Gene Independently of the RIG-I Gene
TLDR
Results indicated that chSTING is an important regulator of chicken innate immune signaling and might be involved in the MDA5 signaling pathway in chicken cells, and these results help with understanding the biological role of STING in innate immunity during evolution. Expand
Treadmilling by FtsZ filaments drives peptidoglycan synthesis and bacterial cell division
TLDR
To understand how these components coordinate to divide cells, visualized their movements relative to the dynamics of cell wall synthesis during cytokinesis and found that the division septum was built at discrete sites that moved around the division plane. Expand
MreB filaments align along greatest principal membrane curvature to orient cell wall synthesis
TLDR
It is proposed that the coupling of MreB filament alignment to shape-reinforcing peptidoglycan synthesis creates a locally-acting, self-organizing mechanism allowing the rapid establishment and stable maintenance of emergent rod shape. Expand
Optical recognition of converted DNA nucleotides for single-molecule DNA sequencing using nanopore arrays.
TLDR
It is shown that signals from multiple nanopores can be detected simultaneously, allowing straightforward parallelization to large nanopore arrays, and showing the feasibility of a nanopore based single-molecule DNA sequencing method, which employs multicolor readout. Expand
Goose RIG-I functions in innate immunity against Newcastle disease virus infections.
TLDR
Animal experiments further support a role of gRIG-I in goose innate immunity against NDV infections by showing increased gRig-I mRNA levels and decreased virus titer in geese lung and air sac post-infection. Expand
Deep Sequencing-Based Transcriptome Profiling Reveals Avian Interferon-Stimulated Genes and Provides Comprehensive Insight into Newcastle Disease Virus-Induced Host Responses
TLDR
The global survey of changes in gene expression performed herein provides new insights into the complicated molecular mechanisms underlying virus and host interactions and will enable the use of new strategies to protect chickens against this virus. Expand
Phylogenetic, antigenic and biological characterization of pigeon paramyxovirus type 1 circulating in China
TLDR
The result suggested that the PPMV-1 strain prevailing in China in the last decade diverged from a common ancestor and was presumably transmitted from Europe. Expand
Single-molecule kinetics of the eukaryotic initiation factor 4AI upon RNA unwinding.
TLDR
It is demonstrated that eIF4AI/eIF4H complex can repetitively unwind RNA hairpins by transitioning between an eIF2AI "open" and a "closed" conformation using the energy derived from ATP hydrolysis, and the results indicate that the large conformational changes undertaken by eif4A during the helicase catalytic cycle are rate limiting. Expand
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