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The syntheses of substituted piperazinyl pyridyl oxazolidinones 8-16 are described. Their in vitro activities against Gram-positive organisms such as Staphylococcus aureus, Staphylococcus… Expand
Tricyclic fused oxazolidinone 3a and 3b have been synthesized as antibacterial agents in 12 and 11 steps respectively. The key intermediates 10a and 10b have been developed via opening of epoxide 9a… Expand
A series of oxazolidinones were synthesized and evaluated as antibacterial agents. They were screened in vitro against a panel of Gram-positive organisms. Compound 9a was found to exhibit activity… Expand
A series of oxazolidinone derivatives carrying sulphonyl group was synthesized and their antibacterial activity was evaluated in vitro. Many of such compounds demonstrated potent antibacterial… Expand
OBJECTIVES AND METHODS YC-20 is a novel oxazolidinone that has targeted activity against Gram-positive bacteria. The in vitro activity of YC-20 and 6 comparators against 522 clinical isolates of… Expand