Yingjian Jiang

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UNLABELLED Tight junctions (TJs) are the structural basis for the intestinal epithelium barrier. Increased intestinal permeability caused by variations in TJ proteins may result in bacterial translocation (BT). There is increasing evidence that BT might contribute to the occurrence and development of cancer cachexia, but the details are not known. Aims, we(More)
BACKGROUND AND OBJECTIVE The aim of the study was to investigate the effects of ceramide-1-phosphate transfer protein (CPTP) on the intestinal epithelial tight junction proteins in patients with severe acute pancreatitis (SAP). METHODS Fifty patients with SAP were classified into two groups according to the presence of bacterial translocation (BT) in the(More)
BACKGROUND AND OBJECTIVE We examined the impact of autophagy activation on bacterial translocation (BT) and tight junction (TJ) proteins in the intestinal mucosa of patients with severe acute pancreatitis (SAP). METHODS Thirty-one SAP patients were divided into two groups, BT(+) and BT(-), according to the presence of BT in the blood, as detected by 16S(More)
To investigate the effect of autophagy on claudin-2 in lipopolysaccharide (LPS) induced hyper-permeability of intestinal epithelial cell. In human colon cancer cell line (Caco-2), the model of intestinal epithelial injury induced by LPS was established, which were LPS group, LPS combined with inhibitor of autophagy (3-Methyladenine, 3-MA) and control group.(More)
GOALS AND BACKGROUND There is increasing evidence that bacterial translocation (BT) might contribute to the occurrence and development of cancer cachexia, but the detailed mechanism remains unknown. Thus, we undertook further investigations into the association of BT with cancer cachexia and the possible pathway. STUDY The colon cancer patients enrolled(More)
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