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An asynchronous algorithm is described for rapidly constructing an overlay network in a peer-to-peer system where all nodes can in principle communicate with each other directly through an underlying network, but each participating node initially has pointers to only a handful of other participants. The output of the mechanism is a linked list of all(More)
A fast self-stabilizing algorithm is described to rapidly construct a balanced overlay network from a directed graph initially with out-degree 1, a natural starting case that arises in peer-to-peer systems where each node attempts to join by contacting some single other node. This algorithm constructs a balanced search tree in time O(W + log n), where W is(More)
This study aims to quantitatively evaluate the potential of diffusion-weighted magnetic resonance imaging (DW-MRI) for differentiating malignant and benign human renal lesions. A systematic literature was performed to identify previous research related to the diagnostic performance of DW-MRI for determining whether human renal lesions were benign or(More)
Increasing evidence suggests that rare and generally deleterious genetic variants might have a strong impact on disease risks of not only Mendelian disease, but also many common diseases. However, identifying such rare variants remains challenging, and novel statistical methods and bioinformatic software must be developed. Hence, we have to extensively(More)
Copy number variations (CNVs) are associated with many complex diseases. Next generation sequencing data enable one to identify precise CNV breakpoints to better under the underlying molecular mechanisms and to design more efficient assays. Using the CIGAR strings of the reads, we develop a method that can identify the exact CNV breakpoints, and in cases(More)
Integration of new DNA into cellular genomes mediates replication of retroviruses and transposons; integration reactions have also been adapted for use in human gene therapy. Tracking the distributions of integration sites is important to characterize populations of transduced cells and to monitor potential outgrow of pathogenic cell clones. Here, we(More)
Analysis of sites of newly integrated DNA in cellular genomes is important to several fields, but methods for analyzing and visualizing these datasets are still under development. Here, we describe tools for data analysis and visualization that take as input integration site data from our INSPIIRED pipeline. Paired-end sequencing allows inference of the(More)
As one common disease that severely affects public health, myocardial infarction has been shown to be related with alternation of serum levels of various microRNAs (miR) including miR-21, miR-34a and miR-328. These molecules can thus work as biological markers for early diagnosis. MiR-122 has been shown to have up-regulation in acute coronary syndrome(More)