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This study investigated cytotoxic effects of Ni(II) to mouse fibroblast cells (L-929) on the level of gene expression profiles with cDNA microarray. The gene expression profiles of L-929 were detected after the cells were cultured in the medium with 200 microm Ni(II) for 24, 48 and 72 h, respectively, and the cytotoxicity of Ni(II) was evaluated with(More)
In order to investigate the molecular effects of gold nanoparticles (GNPs) and cell interaction, after human dermal fibroblasts-fetal (HDF-f) treated with GNPs for 1, 4 and 8 h, the cytotoxicity was evaluated with methylthiazoltetrazolium (MTT) assay. Flow cytometry experiment was used to assess effects of GNPs on cell cycle and apoptosis. Differentially(More)
The unique physicochemical properties of nanoparticles make them promising substrates for application in the medical area. As there are no safety regulations yet, concerns about future health problems are rising. This study was conducted to prepare approximately 20 nm gold nanoparticles (GNPs) by a chemical reduction method and evaluate their cytotoxicity(More)
The aim of the present study is to investigate the molecular effects of Gold nanoparticles (GNPs) on the human dermal fibroblasts-fetal (HDF-f) at the level of protein expression. 20-nm GNPs were prepared using chemical reduction method. After HDF-f were treated with 200 microM GNPs for 1, 4 and 8 h, protein expression profiles were obtained using(More)
The aim of this study is to investigate the mechanism of the effects of gold nanoparticles (GNPs) on human dermal fibroblasts (HDFs) at the microRNA level. First, 20-nm GNPs were synthesized and their effect on HDF proliferation was assayed. SOLiD sequencing technology was then utilized to obtain the microRNA expression profile after GNP treatment. The(More)
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