Yingfeng Zheng

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BACKGROUND The fifth Millennium Development Goal (MDG 5) established the goal of a 75% reduction in the maternal mortality ratio (MMR; number of maternal deaths per 100,000 livebirths) between 1990 and 2015. We aimed to measure levels and track trends in maternal mortality, the key causes contributing to maternal death, and timing of maternal death with(More)
BACKGROUND The Millennium Declaration in 2000 brought special global attention to HIV, tuberculosis, and malaria through the formulation of Millennium Development Goal (MDG) 6. The Global Burden of Disease 2013 study provides a consistent and comprehensive approach to disease estimation for between 1990 and 2013, and an opportunity to assess whether(More)
PURPOSE To assess the prevalence and mechanism of glaucoma in adults living in an urban area of southern China. METHODS Random clustering sampling was used to identify adults aged 50 years and over in Liwan District, Guangzhou. Glaucoma was diagnosed with the ISGEO (International Society of Geographical and Epidemiological Ophthalmology) classification(More)
Central corneal thickness (CCT) is a risk factor of glaucoma, the most common cause of irreversible blindness worldwide. The identification of genetic determinants affecting CCT in the normal population will provide insights into the mechanisms underlying the association between CCT and glaucoma, as well as the pathogenesis of glaucoma itself. We conducted(More)
PURPOSE To assess the prevalence of refractive error and visual impairment in school children in a rural area of southern China. DESIGN Prospective cross-sectional survey. PARTICIPANTS Two thousand four hundred children from junior high schools in Yangxi County. METHODS Random selection of classes from the 3 junior high school grade levels was used to(More)
PURPOSE To assess the prevalence of refractive error and describe the distribution of ocular biometry and its association with refraction in adult Chinese. METHODS Random clustering sampling was used to identify adults aged > or = 50 years in Liwan District, Guangzhou. Refraction was determined by subjective refraction that achieved the best corrected(More)
BACKGROUND China has experienced a remarkable epidemiological and demographic transition during the past three decades. Far less is known about this transition at the subnational level. Timely and accurate assessment of the provincial burden of disease is needed for evidence-based priority setting at the local level in China. METHODS Following the methods(More)
HIV-1 integrase (IN) is a key viral enzymatic protein acting in several viral replication steps, including integration. IN has been shown to be an unstable protein degraded by the N-end rule pathway through the host ubiquitin-proteasome machinery. However, it is still not fully understood how this viral protein is protected from the host(More)
Refractive error is the most common eye disorder worldwide and is a prominent cause of blindness. Myopia affects over 30% of Western populations and up to 80% of Asians. The CREAM consortium conducted genome-wide meta-analyses, including 37,382 individuals from 27 studies of European ancestry and 8,376 from 5 Asian cohorts. We identified 16 new loci for(More)
It has been well recognized that myopia more likely affects East Asians, particularly the Japanese and Chinese population. Although some studies have reported the prevalence of myopia in children living in mainland China, most of these studies are based on subjects with unknown representativeness, non-uniform definition, and measurement methods. A higher(More)