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HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma.
BACKGROUND Long noncoding RNA Hox transcript antisense intergenic RNA (HOTAIR) has been characterized as a negative prognostic factor in breast and colon cancer patients. The clinical significanceExpand
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MicroRNA-7 regulates glioblastoma cell invasion via targeting focal adhesion kinase expression.
BACKGROUND Invasion growth is the most characteristic biological phenotype of glioblastoma, but the molecular mechanism in glioma cell invasion is poorly understood. Recent data have showed thatExpand
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MiR-181d acts as a tumor suppressor in glioma by targeting K-ras and Bcl-2
PurposeRecently, several microRNAs (miRNAs) were reported to be involved in the modulation of glioma development. The aim of our study was to determine the effect of miR-181d on the growth of gliomaExpand
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Overexpressed let-7a inhibits glioma cell malignancy by directly targeting K-ras, independently of PTEN.
BACKGROUND Altered expression of micro(mi)RNAs has been shown to be associated with tumorigenesis and tumor progression. The expression of phosphatase and tensin homolog (PTEN) plays an importantExpand
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Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma.
BACKGROUND Aberrant activation of beta-catenin/TCF4 and STAT3 signaling in glioblastoma multiforme (GBM) has been reported. However, the molecular mechanisms related to this process are still poorlyExpand
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A hybrid neural-genetic algorithm for reservoir water quality management.
A combined neural network and genetic algorithm (GA) was developed for water quality management of Feitsui Reservoir in Taiwan. First, an artificial neural network (ANN) model was employed toExpand
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MiR-1224-5p acts as a tumor suppressor by targeting CREB1 in malignant gliomas
The dysregulation of miR-1224-5p has been reported in several human cancers. However, the expression and function of miR-1224-5p in glioma remains unknown. The aim of our study was to investigate theExpand
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MiRNA-181b suppresses IGF-1R and functions as a tumor suppressor gene in gliomas.
MicroRNAs (miRNAs) are single-stranded, 18- to 23-nt RNA molecules that function as regulators of gene expression. Previous studies have shown that microRNAs play important roles in human cancers,Expand
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MiR‐21 Modulates hTERT Through a STAT3‐Dependent Manner on Glioblastoma Cell Growth
As an important oncogenic miRNA, miR‐21 has been reported to play crucial roles in glioblastoma (GBM) carcinogenesis. However, the precise biological function and molecular mechanism of miR‐21 in GBMExpand
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Long Noncoding RNA Profiles Reveal Three Molecular Subtypes in Glioma
Gliomas are the most lethal type of primary brain tumor in adult. Long noncoding RNAs (lncRNAs), which are involved in the progression of various cancers, may offer a potential gene therapy target inExpand
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