Ying-jun Lai

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To evaluate the separation of T lymphocyte subsets by immunomagnetic beads and to find optimization of strategy for specific binding of antibody-coated beads to cells, two strategies to isolate enriched T lymphocyte subpopulation CD4+ T cells and CD8+ T cells from small volumes (< 5 ml) of peripheral blood by using immunomagnetic beads or complement(More)
A series of 2-[(substituted phenylpiperazin-1-yl)methyl]- and 2-[(substituted phenylpiperidin-1-yl)methyl]-2,3-dihydroimidazo[1,2- c]quinazolin-5(6H)-ones or -5(6H)-thiones, and 3-[(substituted phenylpiperazin-1-yl)methyl]-2,3-dihydroimidazo[1,2-c]quinaz oline derivatives were synthesized, as conformationally restricted analogues of SGB-1534 and ketanserin,(More)
  • Y J Lai, I Lin
  • Physical review. E, Statistical physics, plasmas…
  • 1999
The packings and defects of the strongly coupled two-dimensional Coulomb clusters with particle number N from a few to a few hundred with different forms of mutual repulsion and central confining potentials at zero temperature are investigated using molecular-dynamics simulation through many annealing cycles. The circular symmetry of the confining potential(More)
Matriptase and prostasin, acting as a tightly coupled proteolytic cascade, were reported to be required for epidermal barrier formation in mouse skin. Here we show that, in human skin, matriptase and prostasin are expressed with an inverse pattern over the course of differentiation. Matriptase was detected primarily in epidermal basal keratinocytes and the(More)
OBJECTIVE To investigate the effect of phosphoinositide-3-kinase (PI(3)K) and signal transducer and activator of transcription-6 (STAT(6)) on the proliferation of CD(4)(+) and CD(8)(+) T lymphocytes in bronchial asthma. METHODS CD(4)(+) and CD(8)(+) T lymphocytes of 15 asthmatic patients or 15 healthy control subjects were cultured in vitro from August of(More)
  • Y J Lai, L I
  • Physical review. E, Statistical, nonlinear, and…
  • 2001
The defect excitation and nonuniform melting of a two-dimensional Coulomb cluster with 300 charged particles (interacting with 1/r type force) in a uniform neutralizing background are studied numerically. Intrinsic defects exist around the outer circular shells surrounding the inner triangular lattice. They are the source regions for anisotropic particle(More)
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