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The survival rate of patients with metastatic colorectal cancer (mCRC) has significantly improved with applications of molecularly targeted drugs, such as bevacizumab, and led to a substantial improvement in the overall survival rate. These drugs are capable of specifically targeting the inherent abnormal pathways in cancer cells, which are potentially less(More)
Colorectal cancer is the third most common cause of cancer-related mortality in the whole world (1). About one-third of colorectal carcinoma patients with acute colonic obstruction mandate emergency surgery (2). Current surgical options include intraoperative lavage, colonic segment resection involved with primary anastomosis, subtotal co-lectomy, colostomy(More)
Notch signaling plays a critical role in the maintenance of intestinal homeostasis. The aim of the present study was to investigate the role of Notch signaling in the apoptosis of intestinal epithelial cells after intestinal ischemia reperfusion (I/R) injury. Male C57BL/6 mice were subjected to sham operation or I/R injury. Intestinal tissue samples were(More)
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