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Brain development and function depend on the precise regulation of gene expression. However, our understanding of the complexity and dynamics of the transcriptome of the human brain is incomplete. Here we report the generation and analysis of exon-level transcriptome and associated genotyping data, representing males and females of different ethnicities,(More)
Autism spectrum disorder (ASD) is a complex developmental syndrome of unknown etiology. Recent studies employing exome- and genome-wide sequencing have identified nine high-confidence ASD (hcASD) genes. Working from the hypothesis that ASD-associated mutations in these biologically pleiotropic genes will disrupt intersecting developmental processes to(More)
Culture affects the psychological structure of self and results in two distinct types of self-representation (Western independent self and East Asian interdependent self). However, the neural basis of culture-self interaction remains unknown. We used fMRI to measured brain activity from Western and Chinese subjects who judged personal trait adjectives(More)
The corticospinal (CS) tract is involved in controlling discrete voluntary skilled movements in mammals. The CS tract arises exclusively from layer (L) 5 projection neurons of the cerebral cortex, and its formation requires L5 activity of Fezf2 (Fezl, Zfp312). How this L5-specific pattern of Fezf2 expression and CS axonal connectivity is established with(More)
The most common computer authentication method is to use alphanumerical usernames and passwords. This method has been shown to have significant drawbacks. For example, users tend to pick passwords that can be easily guessed. On the other hand, if a password is hard to guess, then it is often hard to remember. To address this problem, some researchers have(More)
Clostridium tyrobutyricum produces butyrate, acetate, H(2), and CO(2) as its main fermentation products from glucose and xylose. To improve butyric acid and hydrogen production, integrational mutagenesis was used to create a metabolically engineered mutant with inactivated ack gene, encoding acetate kinase (AK) associated with the acetate formation pathway.(More)
The development of the human cerebral cortex is an orchestrated process involving the generation of neural progenitors in the periventricular germinal zones, cell proliferation characterized by symmetric and asymmetric mitoses, followed by migration of post-mitotic neurons to their final destinations in six highly ordered, functionally specialized layers.(More)
Salicylic acid (SA) plays a central role in plant disease resistance, and emerging evidence indicates that auxin, an essential plant hormone in regulating plant growth and development, is involved in plant disease susceptibility. GH3.5, a member of the GH3 family of early auxin-responsive genes in Arabidopsis (Arabidopsis thaliana), encodes a protein(More)
This paper describes a computer vision based system for real-time robust traffic sign detection, tracking, and recognition. Such a framework is of major interest for driver assistance in an intelligent automotive cockpit environment. The proposed approach consists of two components. First, signs are detected using a set of Haar wavelet features obtained(More)
— All of the advantages of application-layer overlay networks arise from two fundamental properties: (1) The network nodes in an overlay network, as opposed to lower-layer network elements such as routers and switches, are end systems and have capabilities far beyond basic operations of storing and forwarding ; and (2) The overlay topology, residing above a(More)