Learn More
Brain development and function depend on the precise regulation of gene expression. However, our understanding of the complexity and dynamics of the transcriptome of the human brain is incomplete. Here we report the generation and analysis of exon-level transcriptome and associated genotyping data, representing males and females of different ethnicities,(More)
The most common computer authentication method is to use alphanumerical usernames and passwords. This method has been shown to have significant drawbacks. For example, users tend to pick passwords that can be easily guessed. On the other hand, if a password is hard to guess, then it is often hard to remember. To address this problem, some researchers have(More)
The development of the human cerebral cortex is an orchestrated process involving the generation of neural progenitors in the periventricular germinal zones, cell proliferation characterized by symmetric and asymmetric mitoses, followed by migration of post-mitotic neurons to their final destinations in six highly ordered, functionally specialized layers.(More)
This paper describes a computer vision based system for real-time robust traffic sign detection, tracking, and recognition. Such a framework is of major interest for driver assistance in an intelligent automotive cockpit environment. The proposed approach consists of two components. First, signs are detected using a set of Haar wavelet features obtained(More)
A G > C polymorphism (rs2910164) is located in the stem region opposite to the mature miR-146a sequence, which results in a change from G:U pair to C:U mismatch in the stem structure of miR-146a precursor. Here, we elucidated the biological significance of this polymorphism, based on cancer association study and cell model system. The cancer association(More)
The corticospinal (CS) tract is involved in controlling discrete voluntary skilled movements in mammals. The CS tract arises exclusively from layer (L) 5 projection neurons of the cerebral cortex, and its formation requires L5 activity of Fezf2 (Fezl, Zfp312). How this L5-specific pattern of Fezf2 expression and CS axonal connectivity is established with(More)
The positive transcription elongation factor b (P-TEFb), consisting of Cdk9 and cyclin T, stimulates RNA polymerase II elongation and cotranscriptional pre-mRNA processing. To accommodate different growth conditions and transcriptional demands, a reservoir of P-TEFb is kept in an inactive state in the multisubunit 7SK snRNP. Under certain stress or disease(More)
Culture affects the psychological structure of self and results in two distinct types of self-representation (Western independent self and East Asian interdependent self). However, the neural basis of culture-self interaction remains unknown. We used fMRI to measured brain activity from Western and Chinese subjects who judged personal trait adjectives(More)
Delay tolerant networks (DTNs) may lack continuous network connectivity. Routing in DTNs is thus challenging since it must handle network partitioning, long delays, and dynamic topology in such networks. In recent years, social-based approaches, which attempt to exploit social behaviors of DTN nodes to make better routing decision, have drawn tremendous(More)
Salicylic acid (SA) plays a central role in plant disease resistance, and emerging evidence indicates that auxin, an essential plant hormone in regulating plant growth and development, is involved in plant disease susceptibility. GH3.5, a member of the GH3 family of early auxin-responsive genes in Arabidopsis (Arabidopsis thaliana), encodes a protein(More)